Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 5/20 | 0.48 |
| ▸ | CNR1 | P21554 | 4/20 | 0.48 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HTR6 | P50406 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.41 |
| ▸ | APP | P05067 | 2/20 | 0.40 |
| ▸ | SNCA | P37840 | 2/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16750284 | 0.87 | PDE4A (0.50) | CNR2CNR1PDE4APDE4BPDE4C | |
| SCHEMBL18070824 | 0.81 | PDE4A (0.46) | CNR2CNR1PDE4APDE4BPDE4C | |
| SCHEMBL6706747 | 0.79 | ALDH1A1 (0.64) | CNR2CNR1PDE4APDE4BPDE4C | |
| SCHEMBL16750294 | 0.78 | PDE4A (0.48) | CNR2CNR1PDE4APDE4BPDE4C | |
| SCHEMBL16750286 | 0.76 | CNR2 (0.47) | CNR2CNR1PDE4APDE4BPDE4C | |
| SCHEMBL5559147 | 0.74 | PDE4A (0.66) | CNR2CNR1PDE4APDE4BPDE4C | |
| SCHEMBL9278001 | 0.74 | PDE4A (0.66) | CNR2CNR1PDE4APDE4BPDE4C | |
| SCHEMBL5557953 | 0.73 | PDE4A (0.62) | CNR2CNR1PDE4APDE4BPDE4C | |
| Hydrochloric Acid SCHEMBL9278006 | 0.73 | PDE4A (0.65) | CNR2CNR1PDE4APDE4BPDE4C | |
| SCHEMBL16750295 | 0.70 | PDE4A (0.48) | CNR2CNR1PDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180162859-A1 | TETRACYCLIC AUTOTAXIN INHIBITORS | ATXCO, INC. | 2018-06-14 | — | — | US | disclosed |
| US-20180162859-A1 | TETRACYCLIC AUTOTAXIN INHIBITORS | ATXCO, INC. | 2018-06-14 | — | — | US | disclosed |
| US-20180162859-A1 | TETRACYCLIC AUTOTAXIN INHIBITORS | ATXCO, INC. | 2018-06-14 | — | — | US | disclosed |
| US-9926318-B2 | Tetracyclic autotaxin inhibitors | PHARMAKEA, INC. (US) | 2018-03-27 | — | — | US | disclosed |
| US-9926318-B2 | Tetracyclic autotaxin inhibitors | PHARMAKEA, INC. (US) | 2018-03-27 | — | — | US | disclosed |
| US-9926318-B2 | Tetracyclic autotaxin inhibitors | PHARMAKEA, INC. (US) | 2018-03-27 | — | — | US | disclosed |
| US-20160264575-A1 | TETRACYCLIC AUTOTAXIN INHIBITORS | DF 2024 IP ACQUISITION, LLC | 2016-09-15 | — | — | US | disclosed |
| US-20160264575-A1 | TETRACYCLIC AUTOTAXIN INHIBITORS | DF 2024 IP ACQUISITION, LLC | 2016-09-15 | — | — | US | disclosed |
| US-20160264575-A1 | TETRACYCLIC AUTOTAXIN INHIBITORS | DF 2024 IP ACQUISITION, LLC | 2016-09-15 | — | — | US | disclosed |
| CN-105764903-A | Tetracyclic autotaxin inhibitors | 法玛克亚公司 | 2016-07-13 | — | — | CN | disclosed |
| WO-2015077502-A1 | TETRACYCLIC AUTOTAXIN INHIBITORS | PHARMAKEA, INC. (US) | 2015-05-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180162859-A1 | TETRACYCLIC AUTOTAXIN INHIBITORS | ENPP2, SERPINB1, UACA | CNR2 4472/4885CNR1 4352/4885PDE4A 2959/4885 |
| US-20160264575-A1 | TETRACYCLIC AUTOTAXIN INHIBITORS | ENPP2, SERPINB1, UACA | CNR2 4472/4885CNR1 4352/4885PDE4A 2959/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.