Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT1 | Q99873 | 1/20 | 0.42 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.37 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.36 |
| ▸ | LMNA | P02545 | 3/20 | 0.36 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.34 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.33 |
| ▸ | CFTR | P13569 | 1/20 | 0.33 |
| ▸ | GOPC | Q9HD26 | 1/20 | 0.33 |
| ▸ | AVPR1A | P37288 | 3/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16775287 | 0.85 | PRMT1 (0.40) | PRMT1AKR1C1OPRM1OPRD1NPSR1 | |
| SCHEMBL16772402 | 0.74 | NPSR1 (0.45) | PRMT1NPSR1LMNAPOLBMAPT | |
| SCHEMBL16772538 | 0.73 | MEN1 (0.59) | PRMT1AKR1C1OPRM1OPRD1NPSR1 | |
| SCHEMBL20468554 | 0.71 | NPSR1 (0.37) | NPSR1LMNAPOLBMAPTSMN1; SMN2 | |
| SCHEMBL18932171 | 0.69 | PRMT1 (0.86) | PRMT1AKR1C1OPRM1OPRD1NPSR1 | |
| SCHEMBL20080293 | 0.67 | MAPT (0.56) | PRMT1AKR1C1OPRM1OPRD1NPSR1 | |
| SCHEMBL16755703 | 0.67 | CYP3A4 (0.44) | LMNAMAPTALOX12MEN1KMT2A | |
| SCHEMBL20468616 | 0.67 | MAPT (0.39) | PRMT1NPSR1LMNAPOLBMAPT | |
| SCHEMBL17109313 | 0.65 | PRMT1 (0.59) | PRMT1AKR1C1OPRM1OPRD1NPSR1 | |
| SCHEMBL9039746 | 0.64 | HCAR2 (0.54) | AKR1C1OPRM1OPRD1NPSR1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180222880-A1 | SecA INHIBITORS AND METHODS OF MAKING AND USING THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-08-09 | — | — | US | disclosed |
| US-9957247-B2 | SecA inhibitors and methods of making and using thereof | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2018-05-01 | — | — | US | disclosed |
| US-20150152077-A1 | SecA Inhibitors and Methods of Making and Using Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180222880-A1 | SecA INHIBITORS AND METHODS OF MAKING AND USING THEREOF | SEC61B, SEC61A1, SEC23A | PRMT1 2590/4885AKR1C1 3973/4885OPRM1 4524/4885 |
| US-20150152077-A1 | SecA Inhibitors and Methods of Making and Using Thereof | SEC61B, SEC61A1, SEC23A | PRMT1 2590/4885AKR1C1 3973/4885OPRM1 4524/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.