Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 5/20 | 0.95 |
| ▸ | MEN1 | O00255 | 4/20 | 0.95 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.95 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.95 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.95 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.95 |
| ▸ | HPGD | P15428 | 2/20 | 0.95 |
| ▸ | PPARG | P37231 | 1/20 | 0.95 |
| ▸ | HTT | P42858 | 1/20 | 0.95 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.95 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.95 |
| ▸ | ACMSD | Q8TDX5 | 2/20 | 0.71 |
| ▸ | KDM1A | O60341 | 9/20 | 0.67 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | DCUN1D1 | Q96GG9 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16772559 | 0.86 | KMT2A (0.71) | KMT2AMEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL17548441 | 0.86 | KMT2A (0.78) | KMT2AMEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL16772545 | 0.85 | MEN1 (0.69) | KMT2AMEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL17548498 | 0.83 | ACMSD (1.00) | KMT2AMEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL16772582 | 0.81 | MEN1 (0.65) | KMT2AMEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL29114049 | 0.80 | ACMSD (0.68) | KMT2AMEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL30613089 | 0.80 | ACMSD (0.68) | KMT2AMEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL6218562 | 0.78 | KMT2A (0.76) | KMT2AMEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL16772558 | 0.78 | ALDH1A1 (0.60) | KMT2AMEN1CYP1A2CYP2C9CYP2C19 | |
| SCHEMBL15955491 | 0.77 | MEN1 (0.65) | KMT2AMEN1CYP1A2CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180222880-A1 | SecA INHIBITORS AND METHODS OF MAKING AND USING THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-08-09 | — | — | US | disclosed |
| US-20180222880-A1 | SecA INHIBITORS AND METHODS OF MAKING AND USING THEREOF | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2018-08-09 | — | — | US | disclosed |
| US-9957247-B2 | SecA inhibitors and methods of making and using thereof | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2018-05-01 | — | — | US | disclosed |
| US-9957247-B2 | SecA inhibitors and methods of making and using thereof | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. (US) | 2018-05-01 | — | — | US | disclosed |
| US-20150152077-A1 | SecA Inhibitors and Methods of Making and Using Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-06-04 | — | — | US | disclosed |
| US-20150152077-A1 | SecA Inhibitors and Methods of Making and Using Thereof | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180222880-A1 | SecA INHIBITORS AND METHODS OF MAKING AND USING THEREOF | SEC61B, SEC61A1, SEC23A | KMT2A 4137/4885MEN1 2848/4885CYP1A2 3004/4885 |
| US-20150152077-A1 | SecA Inhibitors and Methods of Making and Using Thereof | SEC61B, SEC61A1, SEC23A | KMT2A 4137/4885MEN1 2848/4885CYP1A2 3004/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.