SCHEMBL16774585

SCHEMBL16774585

CC(C)(C)N(C(=O)O)c1ncsc1I

nearest known ligand 0.33

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.33
PKM P14618 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28935787 0.70 KDM4E (0.33) KDM4EPKM
SCHEMBL28935679 0.70
SCHEMBL1875012 0.68 LMNA (0.37) KDM4E
SCHEMBL345613 0.67 KDM4E (0.36) KDM4E
SCHEMBL2591235 0.67 CNR2 (0.32)
SCHEMBL28963268 0.67 LMNA (0.30)
SCHEMBL27695177 0.66
SCHEMBL16774583 0.66 KDM4E (0.40) KDM4E
SCHEMBL16774730 0.65 CDC7 (0.43) KDM4E
SCHEMBL28935738 0.64 RAB9A (0.37) KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2513071-B1 THIAZOLEDERIVATES FOR THE TREATMENT OF DISEASES SUCH AS CANCER MERCK PATENT GMBH (DE) 2015-06-17 EP claimed
CN-115611895-A Arylamino derivative estrogen receptor modulators and uses thereof 四川海思科制药有限公司 2023-01-17 CN disclosed
EP-2513071-B1 THIAZOLEDERIVATES FOR THE TREATMENT OF DISEASES SUCH AS CANCER MERCK PATENT GMBH (DE) 2015-06-17 EP disclosed