Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 2/20 | 0.43 |
| ▸ | BCR | P11274 | 2/20 | 0.43 |
| ▸ | RPS6KA3 | P51812 | 3/20 | 0.41 |
| ▸ | RPS6KA2 | Q15349 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | DRD2 | P14416 | 3/20 | 0.40 |
| ▸ | PRKCI | P41743 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | CAMK2D | Q13557 | 2/20 | 0.38 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.38 |
| ▸ | TEK | Q02763 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | KIT | P10721 | 1/20 | 0.36 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.36 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16776270 | 0.95 | ABL1 (0.42) | ABL1BCRRPS6KA3RPS6KA2HTR1A | |
| SCHEMBL16776055 | 0.88 | KARS1 (0.49) | ABL1BCRHTR1APRKCIJAK2 | |
| SCHEMBL19365744 | 0.86 | ABL1 (0.43) | ABL1BCRHTR1ADRD2JAK2 | |
| SCHEMBL16775982 | 0.85 | CACNA1G (0.43) | ABL1BCRRPS6KA3RPS6KA2TEK | |
| SCHEMBL16776187 | 0.85 | RPS6KA3 (0.41) | ABL1BCRRPS6KA3RPS6KA2MAPKAPK2 | |
| SCHEMBL19670393 | 0.84 | ABL1 (0.42) | ABL1BCRHTR1ADRD2JAK2 | |
| SCHEMBL16775986 | 0.83 | SLC27A1 (0.36) | ABL1BCRHTR1APRKCIJAK2 | |
| SCHEMBL16785576 | 0.82 | HTR2A (0.41) | RPS6KA3RPS6KA2MAPTSMN1; SMN2KIT | |
| SCHEMBL16776271 | 0.82 | RPS6KA3 (0.40) | RPS6KA3RPS6KA2HTR1ADRD2MAPT | |
| SCHEMBL16775987 | 0.82 | KARS1 (0.36) | ABL1BCRHTR1APRKCIJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | GLAXOSMITHKLINE LLC | 2015-06-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150152108-A1 | SUBSTITUTED BRIDGED UREA ANALOGS AS SIRTUIN MODULATORS | SIRT1, SIRT3, SIRT2 | ABL1 4089/4885BCR 3239/4885RPS6KA3 2368/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.