Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABL1 | P00519 | 1/20 | 0.42 |
| ▸ | BCR | P11274 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | TEK | Q02763 | 1/20 | 0.39 |
| ▸ | CACNA1G | O43497 | 7/20 | 0.38 |
| ▸ | CACNA1H | O95180 | 7/20 | 0.38 |
| ▸ | CACNA1I | Q9P0X4 | 7/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | HTR2A | P28223 | 2/20 | 0.37 |
| ▸ | HTR2C | P28335 | 2/20 | 0.37 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.37 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19365744 | 0.90 | ABL1 (0.43) | ABL1BCRALDH1A1MAPTLMNA | |
| SCHEMBL19669985 | 0.89 | KARS1 (0.43) | ABL1BCRTEKJAK2CAMK2D | |
| SCHEMBL19670429 | 0.87 | BRAF (0.40) | — | |
| SCHEMBL19670388 | 0.86 | CACNA1G (0.46) | ABL1BCRTEKCACNA1GCACNA1H | |
| SCHEMBL19670179 | 0.86 | HTR2C (0.46) | ABL1BCRCACNA1GCACNA1HCACNA1I | |
| SCHEMBL19670263 | 0.86 | DHFR (0.37) | ABL1BCRTEKJAK2CAMK2D | |
| SCHEMBL19865050 | 0.85 | HTR2C (0.40) | ALDH1A1MAPTCACNA1GCACNA1HCACNA1I | |
| SCHEMBL19670251 | 0.85 | MLLT1 (0.39) | ABL1BCRALDH1A1MAPTTRPV3 | |
| SCHEMBL19670589 | 0.84 | HTR2C (0.42) | ABL1CACNA1GCACNA1HCACNA1IHTR2A | |
| SCHEMBL16775993 | 0.84 | ABL1 (0.43) | ABL1BCRALDH1A1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |