Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 11/20 | 0.34 |
| ▸ | GSK3B | P49841 | 10/20 | 0.34 |
| ▸ | HTR1A | P08908 | 2/20 | 0.34 |
| ▸ | WNT1 | P04628 | 7/20 | 0.33 |
| ▸ | BRAF | P15056 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | PORCN | Q9H237 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.32 |
| ▸ | MAP3K5 | Q99683 | 1/20 | 0.31 |
| ▸ | CCR3 | P51677 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19670492 | 0.88 | DYRK1A (0.42) | DYRK1AGSK3BWNT1 | |
| SCHEMBL19670332 | 0.88 | BRAF (0.41) | DYRK1AGSK3BWNT1BRAFCCR3 | |
| SCHEMBL19670659 | 0.87 | DYRK1A (0.34) | DYRK1AGSK3BWNT1BRAFCCR3 | |
| SCHEMBL19670318 | 0.85 | MTOR (0.36) | DYRK1AGSK3BHTR1AWNT1BRAF | |
| SCHEMBL16776420 | 0.85 | PIM1 (0.34) | DYRK1AGSK3BHTR1AWNT1BRAF | |
| SCHEMBL17618866 | 0.84 | HTR1A (0.34) | DYRK1AGSK3BHTR1AWNT1BRAF | |
| SCHEMBL19364786 | 0.78 | CYP3A4 (0.37) | DYRK1AGSK3BHTR1AWNT1BRAF | |
| SCHEMBL19865030 | 0.77 | DYRK1A (0.40) | DYRK1AGSK3BWNT1BRAF | |
| SCHEMBL19670328 | 0.77 | DYRK1A (0.44) | DYRK1AGSK3BWNT1 | |
| SCHEMBL19670660 | 0.76 | HDAC3 (0.37) | DYRK1AGSK3BWNT1BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9834558-B2 | Substituted bridged urea analogs as sirtuin modulators | GLAXOSMITHKLINE LLC (US) | 2017-12-05 | — | — | US | disclosed |