Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 9/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 9/20 | 0.40 |
| ▸ | CXCR4 | P61073 | 7/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
| ▸ | HRH1 | P35367 | 1/20 | 0.38 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.37 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | CCR2 | P41597 | 1/20 | 0.35 |
| ▸ | CXCL12 | P48061 | 1/20 | 0.35 |
| ▸ | BLM | P54132 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1678646 | 0.84 | ADRB1 (0.43) | CXCR4SMN1; SMN2HRH1TDP1USP2 | |
| SCHEMBL8064202 | 0.72 | ALDH1A1 (0.41) | SMN1; SMN2TDP1MEN1KMT2A | |
| SCHEMBL5551088 | 0.69 | ADRB1 (0.43) | CHRNB2CHRNA4SMN1; SMN2HRH1TDP1 | |
| SCHEMBL17351867 | 0.67 | HRH1 (0.77) | CHRNB2CHRNA4SMN1; SMN2HRH1TDP1 | |
| SCHEMBL336034 | 0.64 | CXCR4 (0.50) | CHRNB2CHRNA4CXCR4SMN1; SMN2TDP1 | |
| Piperazine SCHEMBL7791137 | 0.63 | CXCR4 (0.89) | CXCR4SMN1; SMN2TDP1MEN1CHRM2 | |
| SCHEMBL17201382 | 0.61 | CXCR4 (0.47) | CHRNB2CHRNA4CXCR4SMN1; SMN2TDP1 | |
| SCHEMBL20853807 | 0.60 | CXCR4 (0.44) | CHRNB2CHRNA4CXCR4SMN1; SMN2HRH1 | |
| SCHEMBL3999349 | 0.60 | CXCR4 (0.53) | CXCR4SMN1; SMN2TDP1MEN1CHRM2 | |
| SCHEMBL29095229 | 0.60 | CXCR4 (0.53) | CXCR4SMN1; SMN2TDP1MEN1CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7928096-B2 | Polydiazeniumdiolated cyclic polyamines with polyphasic nitric oxide release and related compounds, compositions comprising same and methods of using same | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2011-04-19 | — | — | US | disclosed |
| US-20090068248-A1 | POLYDIAZENIUMDIOLATED CYCLIC POLYAMINES WITH POLYPHASIC NITRIC OXIDE RELEASE AND RELATED COMPOUNDS, COMPOSITIONS COMPRISING SAME AND METHODS OF USING SAME | THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HE (US) | 2009-03-12 | — | — | US | disclosed |
| US-7468435-B2 | Polydiazeniumdiolated cyclic polyamines with polyphasic nitric oxide release and related compounds, compositions comprising same and methods of using same | THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES (US) | 2008-12-23 | — | — | US | disclosed |
| US-20050148566-A1 | Polydiazeniumdiolated cyclic polyamines with polyphasic nitric oxide release and related compounds, compositions comprising same and methods of using same | THE GOVERNMENT OF THE USA, AS REP. BY THE SECRETARY, DEPT. OF HEALTH & HUMAN SERVICES (US) | 2005-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090068248-A1 | POLYDIAZENIUMDIOLATED CYCLIC POLYAMINES WITH POLYPHASIC NITRIC OXIDE RELEASE AND RELATED COMPOUNDS, COMPOSITIONS COMPRISING SAME AND METHODS OF USING SAME | NOS2, ARG2, NOS1 | CHRNB2 1672/4885CHRNA4 2980/4885CXCR4 4393/4885 |
| US-20050148566-A1 | Polydiazeniumdiolated cyclic polyamines with polyphasic nitric oxide release and related compounds, compositions comprising same and methods of using same | NOS2, ARG2, NOS1 | CHRNB2 1672/4885CHRNA4 2980/4885CXCR4 4393/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.