Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 4/20 | 0.35 |
| ▸ | SLC6A9 | P48067 | 9/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | SCN4A | P35499 | 1/20 | 0.32 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.32 |
| ▸ | HRH1 | P35367 | 2/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16784651 | 0.93 | POLB (0.37) | SCN9ASLC6A9KCNH2POLBHRH1 | |
| SCHEMBL16229805 | 0.91 | SLC6A9 (0.38) | SCN9ASLC6A9KCNH2HRH1 | |
| SCHEMBL16229812 | 0.90 | SLC6A9 (0.39) | SLC6A9 | |
| SCHEMBL16784624 | 0.88 | SLC6A9 (0.46) | SCN9ASLC6A9KCNH2POLBSMN1; SMN2 | |
| SCHEMBL16229750 | 0.87 | SLC6A9 (0.46) | SLC6A9KCNH2 | |
| SCHEMBL16229778 | 0.87 | NR1D1 (0.33) | — | |
| SCHEMBL16784638 | 0.85 | LMNA (0.34) | SLC6A9SMN1; SMN2 | |
| SCHEMBL16784640 | 0.84 | SLC6A9 (0.41) | SLC6A9KCNH2POLBSMN1; SMN2 | |
| SCHEMBL16229777 | 0.83 | SLC6A9 (0.51) | SLC6A9KCNH2 | |
| SCHEMBL16784639 | 0.82 | SLC6A9 (0.45) | SLC6A9KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051280-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-09 | — | — | US | disclosed |