Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | ADRA1D | P25100 | 7/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.32 |
| ▸ | HTR1A | P08908 | 4/20 | 0.31 |
| ▸ | HTR7 | P34969 | 4/20 | 0.31 |
| ▸ | DRD2 | P14416 | 2/20 | 0.31 |
| ▸ | HTR2A | P28223 | 2/20 | 0.31 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.31 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.31 |
| ▸ | HTR6 | P50406 | 2/20 | 0.31 |
| ▸ | HTR2C | P28335 | 2/20 | 0.31 |
| ▸ | HRH1 | P35367 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16784635 | 0.93 | SCN9A (0.35) | POLBSLC6A9SCN9AHRH1KCNH2 | |
| SCHEMBL16229805 | 0.92 | SLC6A9 (0.38) | SLC6A9ADRA1DSCN9AHTR1AHTR7 | |
| SCHEMBL16229812 | 0.91 | SLC6A9 (0.39) | SLC6A9HTR6 | |
| SCHEMBL16784639 | 0.89 | SLC6A9 (0.45) | SLC6A9ADRA1DHTR1AHTR7DRD2 | |
| SCHEMBL16784625 | 0.88 | SLC6A9 (0.39) | POLBSLC6A9ADRA1DSCN9AHTR1A | |
| SCHEMBL16229754 | 0.87 | RORC (0.32) | POLBHTR2AHTR2C | |
| SCHEMBL16229759 | 0.85 | RORC (0.33) | POLBHTR6 | |
| SCHEMBL16229753 | 0.85 | SLC6A9 (0.41) | POLBSLC6A9ADRA1DHTR1AHTR7 | |
| SCHEMBL16229773 | 0.84 | SLC6A9 (0.45) | SLC6A9KCNH2 | |
| SCHEMBL16229775 | 0.84 | DGAT1 (0.36) | SLC6A9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051280-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-09 | — | — | US | disclosed |