Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1D1 | P20393 | 2/20 | 0.33 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | SLC18A2 | Q05940 | 1/20 | 0.30 |
| ▸ | ASAH1 | Q13510 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16229754 | 0.93 | RORC (0.32) | NR1D1 | |
| SCHEMBL16784638 | 0.91 | LMNA (0.34) | NR1D1 | |
| SCHEMBL16229769 | 0.91 | DPP4 (0.34) | PKM | |
| SCHEMBL16229795 | 0.90 | GALR3 (0.35) | NR1D1PKM | |
| SCHEMBL16784635 | 0.87 | SCN9A (0.35) | — | |
| SCHEMBL16229782 | 0.86 | SLC6A9 (0.39) | HTR6PKM | |
| SCHEMBL16229755 | 0.86 | TBXAS1 (0.36) | TBXAS1PKMSLC18A2 | |
| SCHEMBL16229759 | 0.84 | RORC (0.33) | HTR6 | |
| SCHEMBL16229784 | 0.83 | DPP4 (0.34) | PKM | |
| SCHEMBL16229798 | 0.82 | HTR6 (0.36) | HTR6PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051280-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-09 | — | — | US | disclosed |
| US-8883839-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | ABBOTT LABORATORIES (US) | 2014-11-11 | — | — | US | disclosed |