Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORC | P51449 | 2/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.31 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.30 |
| ▸ | MGAT3 | Q09327 | 1/20 | 0.30 |
| ▸ | MGAT2 | Q10469 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | NR1D1 | P20393 | 1/20 | 0.30 |
| ▸ | HTR2A | P28223 | 3/20 | 0.30 |
| ▸ | HTR2C | P28335 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16229778 | 0.93 | NR1D1 (0.33) | NR1D1 | |
| SCHEMBL16229769 | 0.92 | DPP4 (0.34) | RORC | |
| SCHEMBL16229759 | 0.92 | RORC (0.33) | RORCPOLB | |
| SCHEMBL16229795 | 0.91 | GALR3 (0.35) | NR1D1 | |
| SCHEMBL16229775 | 0.89 | DGAT1 (0.36) | DGAT1MGAT3MGAT2 | |
| SCHEMBL16784651 | 0.87 | POLB (0.37) | POLBHTR2AHTR2C | |
| SCHEMBL16229799 | 0.87 | SLC6A9 (0.33) | DGAT1MGAT3MGAT2HTR2AHTR2C | |
| SCHEMBL16784638 | 0.84 | LMNA (0.34) | NR1D1 | |
| SCHEMBL16229784 | 0.84 | DPP4 (0.34) | RORCGAA | |
| SCHEMBL16784634 | 0.83 | POLB (0.35) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9051280-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-06-09 | — | — | US | disclosed |
| US-8883839-B2 | Tetraline and indane derivatives, pharmaceutical compositions containing them, and their use in therapy | ABBOTT LABORATORIES (US) | 2014-11-11 | — | — | US | disclosed |