Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 10/20 | 0.74 |
| ▸ | HDAC8 | Q9BY41 | 10/20 | 0.74 |
| ▸ | HDAC6 | Q9UBN7 | 10/20 | 0.74 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.54 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2554554 | 0.84 | HDAC1 (0.74) | HDAC1HDAC8HDAC6ALDH1A1PDE4B | |
| SCHEMBL19382473 | 0.84 | HDAC1 (0.74) | HDAC1HDAC8HDAC6ALDH1A1PDE4B | |
| SCHEMBL12377859 | 0.84 | HDAC1 (0.58) | HDAC1HDAC8HDAC6ALDH1A1PDE4B | |
| SCHEMBL6706804 | 0.81 | ALDH1A1 (0.70) | HDAC1HDAC8HDAC6ALDH1A1PDE4B | |
| SCHEMBL27768646 | 0.81 | ALDH1A1 (0.74) | HDAC1HDAC8HDAC6ALDH1A1PDE4B | |
| SCHEMBL287420 | 0.81 | ALDH1A1 (0.74) | HDAC1HDAC8HDAC6ALDH1A1PDE4B | |
| SCHEMBL3436645 | 0.81 | HDAC1 (0.65) | HDAC1HDAC8HDAC6ALDH1A1GAA | |
| SCHEMBL6386434 | 0.81 | HDAC1 (0.65) | HDAC1HDAC8HDAC6ALDH1A1PDE4B | |
| SCHEMBL7420484 | 0.80 | HDAC1 (0.68) | HDAC1HDAC8HDAC6ALDH1A1PDE4B | |
| SCHEMBL12339938 | 0.80 | HDAC1 (0.63) | HDAC1HDAC8HDAC6ALDH1A1PDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230365927-A1 | COMPOSITION AND METHOD FOR TRANSDIFFERENTIATING NON-NEURONAL CELLS INTO NEURONS | INSTITUTE OF ZOOLOGY, CHINESE ACADEMY OF SCIENCES (CN) | 2023-11-16 | — | — | US | claimed |
| EP-4230731-A1 | COMPOSITION AND METHOD FOR TRANSDIFFERENTIATING NON-NEURONAL CELLS INTO NEURONS | Institute Of Zoology, Chinese Academy Of Sciences (CN) | 2023-08-23 | — | — | EP | claimed |
| WO-2022077549-A1 | COMPOSITION AND METHOD FOR TRANSDIFFERENTIATING NON-NEURONAL CELLS INTO NEURONS | 中国科学院动物研究所 | 2022-04-21 | — | — | WO | claimed |
| CN-114369572-A | Composition and method for transdifferentiating non-neuronal cells into neurons | 中国科学院动物研究所 | 2022-04-19 | — | — | CN | claimed |
| US-20230365927-A1 | COMPOSITION AND METHOD FOR TRANSDIFFERENTIATING NON-NEURONAL CELLS INTO NEURONS | INSTITUTE OF ZOOLOGY, CHINESE ACADEMY OF SCIENCES (CN) | 2023-11-16 | — | — | US | disclosed |
| US-20230310400-A9 | SYNTHESIS OF SMALL MOLECULE HISTONE DEACETYLASE 6 DEGRADERS, COMPOUNDS FORMED THEREBY, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2023-10-05 | — | — | US | disclosed |
| EP-4230731-A1 | COMPOSITION AND METHOD FOR TRANSDIFFERENTIATING NON-NEURONAL CELLS INTO NEURONS | Institute Of Zoology, Chinese Academy Of Sciences (CN) | 2023-08-23 | — | — | EP | disclosed |
| WO-2022077549-A1 | COMPOSITION AND METHOD FOR TRANSDIFFERENTIATING NON-NEURONAL CELLS INTO NEURONS | 中国科学院动物研究所 | 2022-04-21 | — | — | WO | disclosed |
| CN-114369572-A | Composition and method for transdifferentiating non-neuronal cells into neurons | 中国科学院动物研究所 | 2022-04-19 | — | — | CN | disclosed |
| EP-2609091-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | Lead Discovery Center GmbH (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012028332-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | LEAD DISCOVERY CENTER GMBH (DE) | 2012-03-08 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230310400-A9 | SYNTHESIS OF SMALL MOLECULE HISTONE DEACETYLASE 6 DEGRADERS, COMPOUNDS FORMED THEREBY, AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | HDAC1, HDAC6, HDAC3 | HDAC1 1/4885HDAC8 5/4885HDAC6 2/4885 |
| US-20230365927-A1 | COMPOSITION AND METHOD FOR TRANSDIFFERENTIATING NON-NEURONAL CELLS INTO NEURONS | MYO1B, MYH14, MYO3A | HDAC1 1178/4885HDAC8 702/4885HDAC6 710/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.