Sugi Predict

Sugi Predict / Compounds / SCHEMBL1679062

SCHEMBL1679062

SCHEMBL1679062

COC(=O)C(C)c1ccc(Cl)cc1

nearest known ligand 0.62

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
▸ L3MBTL1 Q9Y468 2/20 0.54
▸ HPGD P15428 1/20 0.50
▸ FFAR2 O15552 1/20 0.49
▸ SLC6A2 P23975 1/20 0.47
▸ SLC6A4 P31645 1/20 0.47
▸ SLC6A3 Q01959 1/20 0.47
▸ MT-CO2 P00403 1/20 0.46
▸ PTGS1 P23219 1/20 0.46
▸ PTGS2 P35354 1/20 0.46
▸ PSEN1 P49768 1/20 0.46
▸ PSEN2 P49810 1/20 0.46
▸ APH1B Q8WW43 1/20 0.46
▸ NCSTN Q92542 1/20 0.46
▸ APH1A Q96BI3 1/20 0.46
▸ PSENEN Q9NZ42 1/20 0.46
▸ BRD4 O60885 1/20 0.46
▸ HDAC4 P56524 1/20 0.46
▸ HDAC7 Q8WUI4 1/20 0.46
▸ HDAC5 Q9UQL6 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL31324173 0.91 L3MBTL1 (0.48) L3MBTL1HPGDFFAR2SLC6A2SLC6A4
SCHEMBL12896284 0.88 HPGD (0.53) L3MBTL1HPGDMT-CO2PTGS1PTGS2
SCHEMBL11130803 0.88 HPGD (0.53) L3MBTL1HPGDMT-CO2PTGS1PTGS2
SCHEMBL12424105 0.82 HPGD (0.51) L3MBTL1HPGDMT-CO2PTGS1PTGS2
SCHEMBL1346074 0.82 ESR1 (0.56) HPGDMT-CO2PTGS1PTGS2
SCHEMBL18547195 0.82 HDAC4 (0.57) L3MBTL1FFAR2SLC6A2SLC6A4SLC6A3
SCHEMBL4064082 0.82 ALDH1A1 (0.56) L3MBTL1FFAR2SLC6A2SLC6A4SLC6A3
SCHEMBL1747458 0.82 ESR1 (0.56) HPGDMT-CO2PTGS1PTGS2
SCHEMBL1978245 0.82 HDAC4 (0.57) L3MBTL1FFAR2SLC6A2SLC6A4SLC6A3
SCHEMBL1345145 0.82 ESR1 (0.56) HPGDMT-CO2PTGS1PTGS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 99 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3704117-B1 AZABICYCLO DERIVATIVES FOR TREATING OCULAR DISORDERS ALCON INC (CH) 2026-01-28 — — EP disclosed
US-12247028-B2 Azabicyclo and diazepine derivatives ALCON INC. (CH) 2025-03-11 — — US disclosed
US-20240317686-A1 RORyT MODULATOR, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF SHANGHAI PHARMACEUTICALS HOLDING CO., LTD. (CN) 2024-09-26 — — US disclosed
EP-4429663-A1 HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS Vigil Neuroscience, Inc. (US) 2024-09-18 — — EP disclosed
US-20240132497-A1 AZABICYCLO AND DIAZEPINE DERIVATIVES ALCON INC. (CH) 2024-04-25 — — US disclosed
US-11884666-B2 Azabicyclo and diazepine derivatives ALCON INC. (CH) 2024-01-30 — — US disclosed
EP-4273129-A1 RORgammaT MODULATOR, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF Shanghai Pharmaceuticals Holding Co., Ltd. (CN) 2023-11-08 — — EP disclosed
WO-2023086799-A1 HETEROCYCLIC COMPOUNDS AS TRIGGERING RECEPTOR EXPRESSED ON MYELOID CELLS 2 AGONISTS VIGIL NEUROSCIENCE, INC. (US) 2023-05-19 — — WO disclosed
CN-114308129-B Catalyst composition for olefin alkoxycarbonylation and preparation method and application thereof 中国科学院兰州化学物理研究所 2022-12-06 — — CN disclosed
US-20220267328-A1 AZABICYCLO AND DIAZEPINE DERIVATIVES ALCON INC. (CH) 2022-08-25 — — US disclosed
WO-2000001704-A2 BENZIMIDAZOLES, PRODUCTION THEREOF AND USE THEREOF AS MEDICAMENTS BOEHRINGER INGELHEIM PHARMA KG (DE) 2000-01-13 — — WO disclosed
WO-1999054313-A1 BICYCLIC COMPOUNDS HAVING AN ANTI-THROMBITIC EFFECT BOEHRINGER INGELHEIM PHARMA KG (DE) 1999-10-28 — — WO disclosed
US-4560447-A Electrolytic process for preparation of α-alkylated acetic acid derivatives OTSUKA KAGAKU KABUSHIKI KAISHA (JP) 1985-12-24 — — US disclosed
EP-0151702-A2 Alpha-hydroxyketone acetals SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) 1985-08-21 — — EP disclosed
US-4424394-A Manufacture of arylacetic acids and their esters BASF AKTIENGESELLSCHAFT (DE) 1984-01-03 — — US disclosed
EP-0048136-A2 Process for preparing alpha-aromatic group substituted alkanoic acids or esters thereof SYNTEX PHARMACEUTICALS INTERNATIONAL LIMITED (BM) 1982-03-24 — — EP disclosed
US-4226790-A ALKANOATE SALTS, WITH PEROXY CARBOXYLIC ACID, MANGANESE SALT THE UPJOHN COMPANY (US) 1980-10-07 — — US disclosed
US-4142054-A TRIVALENT THALLIUM SALT THE UPJOHN COMPANY (US) 1979-02-27 — — US disclosed
US-4135051-A ENOL ETHER OF AN ARYL ALKYL KETONE WITH A THALLIJM SALT, REGENERATION OF THALLIUM SALT BY ADDING PERACID AND REACTIVE METAL COMPOUND THE UPJOHN COMPANY (US) 1979-01-16 — — US disclosed
US-4107439-A Process for preparing arylalkanoic acid derivatives THE UPJOHN COMPANY (US) 1978-08-15 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11884666-B2 Azabicyclo and diazepine derivatives CHRM3, CHRM5, CHRNA5 L3MBTL1 4878/4885HPGD 1520/4885FFAR2 421/4885
US-20240132497-A1 AZABICYCLO AND DIAZEPINE DERIVATIVES CHRM3, CHRM5, CHRNA5 L3MBTL1 4878/4885HPGD 1520/4885FFAR2 421/4885
US-20240317686-A1 RORyT MODULATOR, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF RORC, RORB, RORA L3MBTL1 4147/4885HPGD 2005/4885FFAR2 135/4885
US-20220267328-A1 AZABICYCLO AND DIAZEPINE DERIVATIVES CHRM3, CHRM5, CHRNA5 L3MBTL1 4878/4885HPGD 1520/4885FFAR2 421/4885
US-12247028-B2 Azabicyclo and diazepine derivatives CHRM3, CHRM5, CHRNA5 L3MBTL1 4878/4885HPGD 1520/4885FFAR2 421/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.