Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCF1 | P14598 | 3/20 | 0.47 |
| ▸ | TPH1 | P17752 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | BACE1 | P56817 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | CHKA | P35790 | 2/20 | 0.39 |
| ▸ | CHKB | Q9Y259 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16814938 | 1.00 | NCF1 (0.47) | NCF1TPH1KDM4EL3MBTL1KEAP1 | |
| SCHEMBL23708171 | 0.98 | NCF1 (0.48) | NCF1TPH1KDM4EL3MBTL1KEAP1 | |
| SCHEMBL23708106 | 0.83 | ALDH1A1 (0.43) | TPH1KDM4EL3MBTL1BACE1ALDH1A1 | |
| SCHEMBL110730 | 0.78 | NCF1 (0.70) | NCF1KDM4EL3MBTL1KEAP1ALDH1A1 | |
| SCHEMBL16814951 | 0.78 | NCF1 (0.70) | NCF1KDM4EL3MBTL1KEAP1ALDH1A1 | |
| SCHEMBL16793140 | 0.77 | BACE1 (0.55) | KDM4EBACE1ALDH1A1CHKALMNA | |
| SCHEMBL23708502 | 0.77 | KEAP1 (0.56) | NCF1KDM4EL3MBTL1KEAP1ALDH1A1 | |
| SCHEMBL11439643 | 0.77 | ALDH1A1 (0.61) | NCF1KDM4EL3MBTL1KEAP1ALDH1A1 | |
| SCHEMBL111729 | 0.76 | NCF1 (0.72) | NCF1KDM4EL3MBTL1KEAP1ALDH1A1 | |
| SCHEMBL7896012 | 0.76 | ALDH1A1 (0.60) | NCF1TPH1KDM4EL3MBTL1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015089137-A1 | ACYLGUANIDINES AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2015-06-18 | — | — | WO | disclosed |
| WO-2015089137-A1 | ACYLGUANIDINES AS TRYPTOPHAN HYDROXYLASE INHIBITORS | KAROS PHARMACEUTICALS, INC. (US) | 2015-06-18 | — | — | WO | disclosed |