Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.43 |
| ▸ | CA2 | P00918 | 2/20 | 0.41 |
| ▸ | VHL | P40337 | 1/20 | 0.40 |
| ▸ | ELOC | Q15369 | 1/20 | 0.40 |
| ▸ | ELOB | Q15370 | 1/20 | 0.40 |
| ▸ | F10 | P00742 | 5/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.39 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.39 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.39 |
| ▸ | CA12 | O43570 | 1/20 | 0.38 |
| ▸ | CA1 | P00915 | 1/20 | 0.38 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA6 | P23280 | 1/20 | 0.38 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | CA9 | Q16790 | 1/20 | 0.38 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6641850 | 0.85 | VHL (0.57) | P2RX3VHLELOCELOBF10 | |
| SCHEMBL1640426 | 0.84 | ALDH1A1 (0.43) | TDP1P2RX3F10MAPT | |
| SCHEMBL2538719 | 0.78 | F10 (0.39) | P2RX3F10ITGB1ITGA4MEN1 | |
| SCHEMBL16880726 | 0.78 | F10 (0.41) | P2RX3F10ITGB1ITGA4MEN1 | |
| SCHEMBL14490265 | 0.78 | MGLL (0.48) | F10ITGB1ITGA4MEN1MAPT | |
| SCHEMBL85901 | 0.78 | LOXL2 (0.43) | P2RX3CA2F10ITGB1ITGA4 | |
| SCHEMBL1675566 | 0.76 | CA2 (0.47) | CA2F10ITGB1ITGA4NSD2 | |
| SCHEMBL142916 | 0.75 | MEN1 (0.54) | TDP1F10NR1H3MEN1MAPT | |
| SCHEMBL143175 | 0.74 | ALDH1A1 (0.54) | F10MEN1MAPTKMT2A | |
| SCHEMBL8268510 | 0.74 | F10 (0.43) | P2RX3F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3080131-A1 | IMIDAZOPYRIDAZINE COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES | Bristol-Myers Squibb Company (US) | 2016-10-19 | — | — | EP | disclosed |
| WO-2015089143-A1 | IMIDAZOPYRIDAZINE COMPOUNDS USEFUL AS MODULATORS OF IL-12, IL-23 AND/OR IFN ALPHA RESPONSES | BRISTOL-MYERS SQUIBB COMPANY (US) | 2015-06-18 | — | — | WO | disclosed |
| CN-102942520-B | P38 map kinase inhibitors | CHROMA THERAPEUTICS LTD | 2015-03-04 | — | — | CN | disclosed |