Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.49 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | GLA | P06280 | 1/20 | 0.44 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26268982 | 0.86 | POLB (0.62) | POLBALDH1A1TSHRPABPC1HRH3 | |
| Hydrochloric Acid SCHEMBL31567098 | 0.84 | POLB (0.66) | POLBALDH1A1TSHRPABPC1HRH3 | |
| SCHEMBL16795291 | 0.83 | CARM1 (0.47) | POLBMEN1KMT2AMITF | |
| SCHEMBL16795306 | 0.80 | CARM1 (0.47) | HRH3MEN1KMT2A | |
| SCHEMBL9667976 | 0.75 | POLB (0.62) | POLBALDH1A1HRH3MEN1KMT2A | |
| SCHEMBL5680610 | 0.73 | ALDH1A1 (0.59) | POLBALDH1A1PABPC1HRH3KMT2A | |
| SCHEMBL11112228 | 0.73 | POLB (0.96) | POLBALDH1A1HRH3MEN1KMT2A | |
| SCHEMBL16795141 | 0.73 | CXCR3 (0.51) | MEN1KMT2A | |
| SCHEMBL9720678 | 0.73 | HRH3 (0.69) | POLBALDH1A1PABPC1HRH3MEN1 | |
| SCHEMBL1518347 | 0.72 | POLB (0.46) | POLBALDH1A1TSHRHRH3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015086693-A1 | PYRAZOLOPYRIMIDIN-2-YL DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2015-06-18 | — | — | WO | disclosed |