Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 7/20 | 0.62 |
| ▸ | CHRM3 | P20309 | 7/20 | 0.62 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.62 |
| ▸ | OPRM1 | P35372 | 3/20 | 0.60 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13478932 | 0.81 | CHRM4 (0.64) | CHRM2CHRM3CHRM4OPRM1SIGMAR1 | |
| SCHEMBL4871267 | 0.81 | CHRM2 (0.63) | CHRM2CHRM3CHRM4OPRM1SIGMAR1 | |
| SCHEMBL784863 | 0.81 | SIGMAR1 (0.68) | CHRM2CHRM3CHRM4OPRM1SIGMAR1 | |
| SCHEMBL3311545 | 0.80 | ACHE (0.60) | CHRM2CHRM3OPRM1SIGMAR1MEN1 | |
| SCHEMBL1062230 | 0.79 | OPRM1 (0.56) | CHRM2CHRM3OPRM1SIGMAR1KDM4E | |
| SCHEMBL14975135 | 0.79 | OPRM1 (0.53) | CHRM2CHRM3CHRM4OPRM1SIGMAR1 | |
| SCHEMBL7013887 | 0.78 | SIGMAR1 (0.60) | CHRM2CHRM3CHRM4OPRM1SIGMAR1 | |
| SCHEMBL9471248 | 0.78 | SIGMAR1 (0.58) | CHRM2CHRM3OPRM1SIGMAR1 | |
| SCHEMBL1306000 | 0.77 | OPRM1 (0.61) | CHRM2CHRM3CHRM4OPRM1SIGMAR1 | |
| SCHEMBL16291177 | 0.77 | MEN1 (0.68) | CHRM2CHRM3SIGMAR1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015086693-A1 | PYRAZOLOPYRIMIDIN-2-YL DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2015-06-18 | — | — | WO | disclosed |