Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PABPC1 | P11940 | 1/20 | 0.51 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.51 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16795218 | 0.90 | PABPC1 (0.51) | PABPC1SLC2A1HIF1ACYP2C9CYP2C19 | |
| SCHEMBL28690594 | 0.79 | HRH3 (0.53) | KDM4ETSHRALDH1A1LPLLIPG | |
| SCHEMBL20505581 | 0.76 | NPBWR1 (0.45) | HIF1AHTTKMT2AKDM4EMEN1 | |
| SCHEMBL16795329 | 0.76 | ALDH1A1 (0.43) | PABPC1HIF1ACYP2C9CYP2C19CYP2D6 | |
| SCHEMBL12502664 | 0.75 | HIF1A (0.48) | HIF1AROCK1LPLLIPGCA12 | |
| SCHEMBL21682668 | 0.75 | HIF1A (0.50) | HIF1AROCK1LPLLIPGCA12 | |
| SCHEMBL4815568 | 0.75 | LPL (0.44) | HIF1AROCK1LPLLIPGCA12 | |
| SCHEMBL16795372 | 0.73 | HIF1A (0.47) | HIF1ATSHRROCK1LIPGCA12 | |
| SCHEMBL20504895 | 0.73 | NPBWR1 (0.42) | HIF1AHTTKMT2AKDM4EMEN1 | |
| SCHEMBL17045814 | 0.73 | KMT2A (0.43) | PABPC1HIF1ACYP2C9CYP2C19ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015086693-A1 | PYRAZOLOPYRIMIDIN-2-YL DERIVATIVES AS JAK INHIBITORS | ALMIRALL, S.A. (ES) | 2015-06-18 | — | — | WO | disclosed |