Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.40 |
| ▸ | PFKFB3 | Q16875 | 1/20 | 0.40 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16796729 | 0.85 | P2RX4 (0.43) | ALDH1A1HPGDLMNAKMT2AMAPT | |
| SCHEMBL16796607 | 0.82 | P2RX4 (0.41) | ALDH1A1KMT2AMAPTP2RX4 | |
| SCHEMBL16239013 | 0.82 | P2RX4 (0.54) | MMP2MMP9MMP8MMP13ALDH1A1 | |
| SCHEMBL16796643 | 0.81 | METAP2 (0.44) | ALDH1A1HPGDHTTMAPTP2RX4 | |
| SCHEMBL16812977 | 0.81 | GABRA1 (0.51) | ALDH1A1HPGDHTTLMNAMAPT | |
| SCHEMBL16796629 | 0.80 | KMT2A (0.50) | MMP2MMP9MMP8MMP13BRD4 | |
| SCHEMBL16796688 | 0.79 | P2RX4 (0.47) | ALDH1A1HPGDHTTLMNAKMT2A | |
| SCHEMBL16813006 | 0.78 | P2RX4 (0.46) | ALDH1A1HPGDLMNAKMT2AMEN1 | |
| SCHEMBL16796615 | 0.78 | P2RX4 (0.46) | ALDH1A1HPGDKMT2ATP53MAPT | |
| SCHEMBL16796606 | 0.78 | P2RX4 (0.46) | ALDH1A1HPGDLMNAKMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015088565-A1 | P2X4 RECEPTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2015-06-18 | — | — | WO | disclosed |
| WO-2015088565-A1 | P2X4 RECEPTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2015-06-18 | — | — | WO | disclosed |