Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 5/20 | 0.38 |
| ▸ | NR1H3 | Q13133 | 5/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PPARD | Q03181 | 2/20 | 0.38 |
| ▸ | PPARA | Q07869 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16796715 | 0.85 | P2RX4 (0.42) | P2RX4ALDH1A1SMN1; SMN2GABRA1GABRG2 | |
| SCHEMBL16796578 | 0.82 | P2RX4 (0.43) | P2RX4ALDH1A1SMN1; SMN2GABRA1GABRG2 | |
| SCHEMBL16796602 | 0.82 | P2RX4 (0.43) | P2RX4ALDH1A1SMN1; SMN2GABRA1GABRG2 | |
| SCHEMBL16812977 | 0.81 | GABRA1 (0.51) | P2RX4KDM4EALDH1A1HPGDHTT | |
| SCHEMBL16796629 | 0.81 | KMT2A (0.50) | AURKAKDM4ENPC1ALDH1A1RAB9A | |
| SCHEMBL16796597 | 0.81 | MMP2 (0.49) | P2RX4ALDH1A1HPGDHTTMAPT | |
| SCHEMBL16796604 | 0.80 | P2RX4 (0.41) | P2RX4ALDH1A1HTTSMN1; SMN2GABRA1 | |
| SCHEMBL16796688 | 0.80 | P2RX4 (0.47) | P2RX4KDM4EALDH1A1HPGDHTT | |
| SCHEMBL16813007 | 0.79 | P2RX4 (0.62) | P2RX4HTTSMN1; SMN2GABRA1GABRG2 | |
| SCHEMBL16796615 | 0.79 | P2RX4 (0.46) | P2RX4AURKAKDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015088565-A1 | P2X4 RECEPTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2015-06-18 | — | — | WO | disclosed |
| WO-2015088565-A1 | P2X4 RECEPTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2015-06-18 | — | — | WO | disclosed |