Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.50 |
| ▸ | POLB | P06746 | 4/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MMP2 | P08253 | 1/20 | 0.49 |
| ▸ | MMP9 | P14780 | 1/20 | 0.49 |
| ▸ | COMT | P21964 | 1/20 | 0.49 |
| ▸ | MMP8 | P22894 | 1/20 | 0.49 |
| ▸ | MMP13 | P45452 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 4/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | BRD4 | O60885 | 1/20 | 0.45 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16796681 | 0.86 | MAPK1 (0.47) | KMT2AKDM4EMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL16796574 | 0.83 | P2RX4 (0.43) | KMT2ASMN1; SMN2MAPTBRD4MAPK1 | |
| SCHEMBL16796568 | 0.82 | KIF11 (0.46) | KMT2AMEN1ALDH1A1 | |
| SCHEMBL16796643 | 0.81 | METAP2 (0.44) | KDM4EALDH1A1SMN1; SMN2MAPTRAB9A | |
| SCHEMBL16812977 | 0.81 | GABRA1 (0.51) | KDM4EALDH1A1SMN1; SMN2MAPTMAPK1 | |
| SCHEMBL16796597 | 0.80 | MMP2 (0.49) | KMT2APOLBMEN1ALDH1A1MMP2 | |
| SCHEMBL16796623 | 0.80 | P2RX4 (0.43) | KMT2AALDH1A1SMN1; SMN2MAPTMAPK1 | |
| SCHEMBL16813008 | 0.80 | P2RX4 (0.46) | KMT2APOLBMEN1ALDH1A1SMN1; SMN2 | |
| SCHEMBL16796688 | 0.79 | P2RX4 (0.47) | KMT2AKDM4EALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL16796622 | 0.78 | P2RX4 (0.43) | KMT2AALDH1A1SMN1; SMN2MAPTMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015088565-A1 | P2X4 RECEPTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2015-06-18 | — | — | WO | disclosed |
| WO-2015088565-A1 | P2X4 RECEPTOR MODULATING COMPOUNDS AND METHODS OF USE THEREOF | SUNOVION PHARMACEUTICALS INC. (US) | 2015-06-18 | — | — | WO | disclosed |