Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 3/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | GRM5 | P41594 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5199157 | 0.84 | ALDH1A1 (0.41) | PTGS1PTGS2NPC1LMNAKMT2A | |
| SCHEMBL14164034 | 0.66 | ALDH1A1 (0.49) | HSD11B1HSD17B10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9987876 | 0.66 | L3MBTL1 (0.50) | PTGS1PTGS2HSD17B10NPC1RAB9A | |
| SCHEMBL10394013 | 0.66 | PTGS1 (0.66) | PTGS1PTGS2HSD17B10LMNAMAPT | |
| SCHEMBL14678366 | 0.66 | PTGS1 (0.61) | PTGS1PTGS2HSD11B1HSD17B10LMNA | |
| SCHEMBL10083918 | 0.66 | PTGS1 (0.66) | PTGS1PTGS2HSD17B10LMNAMAPT | |
| SCHEMBL1435605 | 0.64 | NPC1 (0.53) | HSD11B1HSD17B10NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL1086652 | 0.64 | PTGS1 (0.47) | PTGS1PTGS2HSD11B1HSD17B10NPC1 | |
| SCHEMBL14258658 | 0.63 | PTGS1 (0.62) | PTGS1PTGS2HSD17B10LMNAMAPT | |
| SCHEMBL1946632 | 0.63 | NPC1 (0.52) | HSD17B10NPC1RAB9ASMN1; SMN2TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-4663982-B2 | — | — | 2011-04-06 | — | — | JP | claimed |
| US-7271192-B2 | Substituted 2-pyrrolidine-2-yl-1H-indole compounds | GRUENENTHAL GMBH (DE) | 2007-09-18 | — | — | US | claimed |
| EP-1451177-B1 | SUBSTITUTED 2-PYRROLIDINE-2-YL-1H-INDOLE DERIVATIVES FOR THE TREATMENT OF MIGRAINE | GRUENENTHAL GMBH (DE) | 2007-03-21 | — | — | EP | claimed |
| JP-2005511694-A | — | — | 2005-04-28 | — | — | JP | claimed |
| US-20050014815-A1 | Substituted 2-pyrrolidine-2-yl-1H-indole compounds | GRUENENTHAL GMBH (DE) | 2005-01-20 | — | — | US | claimed |
| EP-1451177-A1 | SUBSTITUTED 2-PYRROLIDINE-2-YL-1H-INDOLE DERIVATIVES FOR THE TREATMENT OF MIGRAINE | Grünenthal GmbH (DE) | 2004-09-01 | — | — | EP | claimed |
| WO-2003048156-A1 | SUBSTITUTED 2-PYRROLIDINE-2-YL-1H-INDOLE DERIVATIVES FOR THE TREATMENT OF MIGRAINE | Grünenthal GmbH (DE) | 2003-06-12 | — | — | WO | claimed |
| US-7271192-B2 | Substituted 2-pyrrolidine-2-yl-1H-indole compounds | GRUENENTHAL GMBH (DE) | 2007-09-18 | — | — | US | disclosed |
| EP-1451177-B1 | SUBSTITUTED 2-PYRROLIDINE-2-YL-1H-INDOLE DERIVATIVES FOR THE TREATMENT OF MIGRAINE | GRUENENTHAL GMBH (DE) | 2007-03-21 | — | — | EP | disclosed |
| US-20050014815-A1 | Substituted 2-pyrrolidine-2-yl-1H-indole compounds | GRUENENTHAL GMBH (DE) | 2005-01-20 | — | — | US | disclosed |
| EP-1451177-A1 | SUBSTITUTED 2-PYRROLIDINE-2-YL-1H-INDOLE DERIVATIVES FOR THE TREATMENT OF MIGRAINE | Grünenthal GmbH (DE) | 2004-09-01 | — | — | EP | disclosed |
| WO-2003048156-A1 | SUBSTITUTED 2-PYRROLIDINE-2-YL-1H-INDOLE DERIVATIVES FOR THE TREATMENT OF MIGRAINE | Grünenthal GmbH (DE) | 2003-06-12 | — | — | WO | disclosed |
| US-4122189-A | METHYL METHIONINE SULFONIUM SALTS | KAKEN CHEMICAL CO., LTD. (JP) | 1978-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050014815-A1 | Substituted 2-pyrrolidine-2-yl-1H-indole compounds | IDO1, IDO2, TPH2 | PTGS1 364/4885PTGS2 202/4885HSD11B1 1875/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.