Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 3/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1679810 | 0.84 | PTGS1 (0.44) | ALDH1A1TSHRL3MBTL1LMNAMAPT | |
| SCHEMBL15477789 | 0.72 | NR1H4 (0.39) | ALDH1A1TSHRMAPTNPSR1KDM4E | |
| SCHEMBL8131452 | 0.67 | ALDH1A1 (0.40) | ALDH1A1L3MBTL1LMNAMAPTNPSR1 | |
| SCHEMBL8295451 | 0.65 | L3MBTL1 (0.58) | ALDH1A1TSHRL3MBTL1LMNAGAA | |
| SCHEMBL1283334 | 0.64 | ALDH1A1 (0.61) | ALDH1A1TSHRL3MBTL1LMNAGAA | |
| SCHEMBL10394020 | 0.64 | ALDH1A1 (0.61) | ALDH1A1TSHRL3MBTL1LMNAGAA | |
| SCHEMBL1326560 | 0.63 | ALDH1A1 (0.44) | ALDH1A1TSHRL3MBTL1LMNAGAA | |
| SCHEMBL2306450 | 0.62 | ALDH1A1 (0.58) | ALDH1A1TSHRL3MBTL1LMNAGAA | |
| SCHEMBL2471569 | 0.61 | TSHR (0.57) | ALDH1A1TSHRLMNAKMT2ATDP1 | |
| SCHEMBL10163467 | 0.60 | RAB9A (0.49) | ALDH1A1TSHRL3MBTL1LMNAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1067131-B1 | New process for the manufacture of cephalosporin derivatives | BASILEA PHARMACEUTICA AG (CH) | 2007-08-15 | — | — | EP | disclosed |
| EP-0864564-B1 | Method for the preparation of alpha-bromolactam derivatives | BASILEA PHARMACEUTICA AG (CH) | 2002-06-12 | — | — | EP | disclosed |
| US-6384214-B1 | ALKALINE CONVERSION OF PYRROLIDINYL PHOSHONIUM SALT TO YLIDE FOLLOWED BY COUPLING WITH A 5-THIA-1-AZABICYCLOOCTANE 2-ALDEHYDE; ISOMERIZATION INHIBITION | BASILEA PHARMACEUTICA AG (CH) | 2002-05-07 | — | — | US | disclosed |
| EP-0812846-B1 | Preparation of cephem- and isooxacephem derivatives | BASILEA PHARMACEUTICA AG (CH) | 2001-08-16 | — | — | EP | disclosed |
| EP-1067131-A1 | New process for the manufacture of cephalosporin derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 2001-01-10 | — | — | EP | disclosed |
| US-6114541-A | Method for the preparation of α-Bromo-Lactam derivatives | HOFFMANN-LA ROCHE INC. (US) | 2000-09-05 | — | — | US | disclosed |
| US-5919939-A | Preparation of cephem and isooxacephem derivatives | HOFFMANN-LA ROCHE INC. (US) | 1999-07-06 | — | — | US | disclosed |
| US-5883247-A | ACYLATION WITH AMINOTHIAZOLE DERIVATIVE ACTIVATED AS MIXED ANHYDRIDE OF THIOPHOSPHORIC ACID | HOFFMANN-LA ROCHE INC. (US) | 1999-03-16 | — | — | US | disclosed |
| EP-0879237-A1 | ISOOXACEPHEM DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1998-11-25 | — | — | EP | disclosed |
| US-5811419-A | ANTIBIOTICS | HOFFMANN-LA ROCHE INC. (US) | 1998-09-22 | — | — | US | disclosed |
| EP-0864564-A1 | Method for the preparation of alpha-bromolactam derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1998-09-16 | — | — | EP | disclosed |
| EP-0812846-A1 | Preparation of cephem- and isooxacephem derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1997-12-17 | — | — | EP | disclosed |
| WO-1997026260-A1 | ISOOXACEPHEM DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1997-07-24 | — | — | WO | disclosed |