Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD51 | Q06609 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CTSK | P43235 | 1/20 | 0.44 |
| ▸ | TOP1 | P11387 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | KIF11 | P52732 | 3/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.42 |
| ▸ | PDE2A | O00408 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15533905 | 0.86 | RAD51 (0.45) | RAD51ADORA3CTSSCTSKTOP1 | |
| SCHEMBL19262265 | 0.83 | RAD51 (0.45) | RAD51ADORA3CTSSCTSKTOP1 | |
| SCHEMBL3561445 | 0.83 | ALDH1A1 (0.47) | RAD51ADORA3CTSSCTSKTOP1 | |
| SCHEMBL4716132 | 0.83 | RAD51 (0.48) | RAD51ADORA3CTSSCTSKTOP1 | |
| SCHEMBL7873519 | 0.80 | KDM4E (0.50) | RAD51ADORA3CTSSCTSKTOP1 | |
| SCHEMBL1841140 | 0.79 | RAD51 (0.54) | RAD51ADORA3CTSSCTSKTOP1 | |
| SCHEMBL8321136 | 0.79 | RAD51 (0.43) | RAD51ADORA3LMNANPC1RAB9A | |
| SCHEMBL3556359 | 0.79 | ADORA3 (0.50) | RAD51ADORA3NPC1MAPTRAB9A | |
| SCHEMBL3727413 | 0.79 | CTSS (0.49) | RAD51ADORA3CTSSCTSKTOP1 | |
| SCHEMBL15535289 | 0.79 | ADORA3 (0.47) | RAD51ADORA3CTSSCTSKTOP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106458952-B | Heterocycle sulfamide derivatives and drug containing the heterocycle sulfamide derivatives | EA制药株式会社 | 2019-09-27 | — | — | CN | disclosed |
| US-10010551-B2 | Pyrimidinyl-diazospiro compounds | Convergence Pharmaceuticals Limited (GB) | 2018-07-03 | — | — | US | disclosed |
| CN-107849029-A | Cyclopropane derivatives and drugs containing the same | EA制药株式会社 | 2018-03-27 | — | — | CN | disclosed |
| US-20170304303-A1 | Novel Pyrimidinyl-DiazoSpiro Compounds | Convergence Pharmaceuticals Limited (GB) | 2017-10-26 | — | — | US | disclosed |
| US-9737536-B2 | Pyrimidinyl-diazospiro compounds | Convergence Pharmaceuticals Limited (GB) | 2017-08-22 | — | — | US | disclosed |
| CN-106458952-A | Heterocyclic sulfonamide derivative and medicine comprising same | EA制药株式会社 | 2017-02-22 | — | — | CN | disclosed |
| US-20160263115-A1 | Novel Pyrimidinyl-DiazoSpiro Compounds | Convergence Pharmaceuticals Limited (GB) | 2016-09-15 | — | — | US | disclosed |
| US-9376445-B2 | Pyrimidinyl-diazospiro compounds | Convergence Pharmaceuticals Limited (GB) | 2016-06-28 | — | — | US | disclosed |
| US-20150166551-A1 | NOVEL COMPOUNDS | Convergence Pharmaceuticals Limited (GB) | 2015-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150166551-A1 | NOVEL COMPOUNDS | KCNJ2, KCNN2, KCNN3 | RAD51 4815/4885ADORA3 2155/4885CTSS 3956/4885 |
| US-20160263115-A1 | Novel Pyrimidinyl-DiazoSpiro Compounds | TRPV1, KCNJ2, SCN1A | RAD51 4520/4885ADORA3 1622/4885CTSS 4443/4885 |
| US-10010551-B2 | Pyrimidinyl-diazospiro compounds | KCNJ2, TRPV1, SCN2A | RAD51 4436/4885ADORA3 1278/4885CTSS 4417/4885 |
| US-20170304303-A1 | Novel Pyrimidinyl-DiazoSpiro Compounds | TRPV1, KCNJ2, KCNN2 | RAD51 4651/4885ADORA3 1610/4885CTSS 4425/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.