Acetic Acid

Acetic Acid

SCHEMBL1682182

CC(=O)O.CC(=O)O.CC(=O)O.CC(=O)O.CCCCCCCCC(=O)OCC

nearest known ligand 0.67

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ADRA2AADRA2BADRA2CADRB2AGTR1AVPR1AAVPR1BAVPR2BDKRB2CALCRCHRNA3CHRNB4ESR1ESR2GHSRGNRHRGSC1HSPA8MALT1MC1RMC4RNOS1NOS2NOS3OPRK1OXTRRAMP1RAMP2RAMP3SCN5ASSTR1SSTR2SSTR3SSTR4SSTR5dacAdacBdacCfolPftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO

The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 known ✓ P03372 1/20 0.52
DGKA P23743 1/20 0.67
PAM P19021 2/20 0.66
TSHR P16473 4/20 0.56
MAPT P10636 1/20 0.56
CYP1A2 P05177 1/20 0.55
ALDH1A1 P00352 3/20 0.55
LMNA P02545 2/20 0.55
DNM1 Q05193 1/20 0.55
MEN1 O00255 2/20 0.53
KMT2A Q03164 2/20 0.53
KDM4E B2RXH2 1/20 0.53
DUSP3 P51452 1/20 0.53
PPARG P37231 4/20 0.52
PPARD Q03181 4/20 0.52
PPARA Q07869 4/20 0.52
GPR84 Q9NQS5 3/20 0.52
HDAC11 Q96DB2 3/20 0.52
TDP1 Q9NUW8 2/20 0.52
SLC22A6 Q4U2R8 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acetic Acid SCHEMBL6448229 1.00 DGKA (0.67) DGKAPAMTSHRMAPTCYP1A2
Acetic Acid SCHEMBL989180 1.00 DGKA (0.67) DGKAPAMTSHRMAPTCYP1A2
Acetic Acid SCHEMBL5395399 1.00 DGKA (0.67) DGKAPAMTSHRMAPTCYP1A2
Ethyl Tetradecanoate SCHEMBL8330964 1.00 DGKA (0.67) DGKAPAMTSHRMAPTCYP1A2
Acetic Acid SCHEMBL173634 1.00 DGKA (0.67) DGKAPAMTSHRMAPTCYP1A2
Acetic Acid SCHEMBL2213929 1.00 DGKA (0.67) DGKAPAMTSHRMAPTCYP1A2
Acetic Acid SCHEMBL787652 1.00 DGKA (0.67) DGKAPAMTSHRMAPTCYP1A2
Acetic Acid SCHEMBL3028566 1.00 DGKA (0.67) DGKAPAMTSHRMAPTCYP1A2
Acetic Acid SCHEMBL543614 1.00 DGKA (0.67) DGKAPAMTSHRMAPTCYP1A2
Acetic Acid SCHEMBL8469053 1.00 DGKA (0.67) DGKAPAMTSHRMAPTCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112930174-A Methods for synthesizing D3 dopamine receptor agonists 波利科尔疗法公司 2021-06-08 CN disclosed
US-8598123-B2 Peptide analogues PFIZER INC. (US) 2013-12-03 US disclosed
EP-2539358-A1 PEPTIDE ANALOGUES Pfizer Limited (GB) 2013-01-02 EP disclosed
US-20120329724-A1 PEPTIDE ANALOGUES PFIZER LIMITED 2012-12-27 US disclosed
US-20120270819-A1 USE OF COMPOUNDS WITH SGLT-1/SGLT-2 INHIBITOR ACTIVITY FOR PRODUCING MEDICAMENTS FOR TREATMENT OF BONE DISEASE SANOFI (FR) 2012-10-25 US disclosed
CN-102753184-A Use of compounds with sglt-1/sglt-2 inhibitor activity for producing medicaments for treatment of bone diseases SANOFI AVENTIS 2012-10-24 CN disclosed
EP-2482823-A2 USE OF COMPOUNDS WITH SGLT-1/SGLT-2 INHIBITOR ACTIVITY FOR PRODUCING MEDICAMENTS FOR TREATMENT OF BONE DISEASES SANOFI (FR) 2012-08-08 EP disclosed
WO-2011104649-A1 PEPTIDE ANALOGUES PFIZER LIMITED (GB) 2011-09-01 WO disclosed
US-20110207654-A1 PEPTIDE ANALOGUES PFIZER INC. 2011-08-25 US disclosed
WO-2011039338-A2 USE OF COMPOUNDS WITH SGLT-1/SGLT-2 INHIBITOR ACTIVITY FOR PRODUCING MEDICAMENTS FOR TREATMENT OF BONE DISEASES SANOFI-AVENTIS (FR) 2011-04-07 WO disclosed
US-5574164-A 1-alkyl-,1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and related compounds HOESCHT ROUSSEL PHARMACEUTICALS INC. (US) 1996-11-12 US disclosed
US-5571923-A 3-/1-DODECYL/-5-ISOXAZOLEMETHANOL INTERMEDIATE HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1996-11-05 US disclosed
US-5565584-A CHEMICAL INTERMEDIATES HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) 1996-10-15 US disclosed
US-5557006-A 1-Alkyl-, 1-alkenyl-, and 1-alkynylaryl-2-amino-1,3-propanediols and related compounds HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1996-09-17 US disclosed
US-5550247-A ANTIINFLAMMATORY AGENT, ANTITUMOR AGENT, COGNITION ACTIVATORS, BACTERICIDES, FUNGICIDES HOECHST ROUSSEL PHARMACEUTICALS INC. (US) 1996-08-27 US disclosed
US-5534640-A REDUCING INFLAMMATION AND CELL PROLIFERATION, COGNITION ACTIVATORS, BACTERIOSTATS, FUNGISTATS HOECHST ROUSSEL PHARMACEUTICALS INC. (US) 1996-07-09 US disclosed
US-5534636-A ANTIINFLAMMATORY AGENTS, ANTITUMOR AGENT, COGNITION ACTIVATORS,BACTERICIDES, AND FUNGICIDES HOECHST ROUSSEL PHARMACEUTICALS INC. (US) 1996-07-09 US disclosed
US-5519062-A ANTIINFLAMMATORY HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1996-05-21 US disclosed
US-5488063-A ANTIINFLAMMATORY, ANTICARACINOGENIC AGENTS; BACTERICIDES, FUNGICIDES HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1996-01-30 US disclosed
US-5488061-A ANTIINFLAMMATORY, ANTICARACINOGENIC AGENTS; BACTERICIDES, FUNGICIDES HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1996-01-30 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120329724-A1 PEPTIDE ANALOGUES OPRL1, OGFR, OPRM1 ESR1 978/4885DGKA 3870/4885PAM 257/4885
US-20120270819-A1 USE OF COMPOUNDS WITH SGLT-1/SGLT-2 INHIBITOR ACTIVITY FOR PRODUCING MEDICAMENTS FOR TREATMENT OF BONE DISEASE SLC5A1, SLC5A2, SOST ESR1 675/4885DGKA 1930/4885PAM 1781/4885
US-20110207654-A1 PEPTIDE ANALOGUES OPRL1, OGFR, OPRM1 ESR1 978/4885DGKA 3870/4885PAM 257/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.