Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.52 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.42 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.42 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.42 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.42 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.41 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14893135 | 0.80 | MTNR1A (0.74) | MTNR1AMTNR1BKMT2ACNR1HPGD | |
| SCHEMBL29718486 | 0.76 | L3MBTL1 (0.43) | MAPK1KMT2A | |
| SCHEMBL28080077 | 0.76 | PDE4A (0.44) | LIPGKMT2AHPGD | |
| SCHEMBL13167369 | 0.76 | LIPG (0.49) | MTNR1AMTNR1BMAPK1LIPGKMT2A | |
| SCHEMBL29474958 | 0.74 | SLC6A2 (0.41) | LIPGKMT2A | |
| SCHEMBL9843826 | 0.74 | TAAR1 (0.58) | KMT2A | |
| SCHEMBL3361287 | 0.74 | SLC6A2 (0.41) | LIPGKMT2A | |
| SCHEMBL34463098 | 0.74 | TAAR1 (0.58) | KMT2A | |
| SCHEMBL28335010 | 0.73 | MTNR1A (0.63) | MTNR1AMTNR1BNOTUMCNR1HPGD | |
| SCHEMBL29718735 | 0.71 | CXCL8 (0.58) | KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3082810-A1 | ERK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2016-10-26 | — | — | EP | disclosed |
| EP-2900223-A1 | NOVEL COMPOUNDS THAT ARE ERK INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2015-08-05 | — | — | EP | disclosed |
| WO-2015094929-A1 | ERK INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2015-06-25 | — | — | WO | disclosed |