Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 4/20 | 0.50 |
| ▸ | HPGD | P15428 | 3/20 | 0.50 |
| ▸ | NPC1 | O15118 | 3/20 | 0.50 |
| ▸ | F10 | P00742 | 1/20 | 0.50 |
| ▸ | XBP1 | P17861 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | AHR | P35869 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | STK33 | Q9BYT3 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17938566 | 0.92 | GPR35 (0.53) | GPR35MAPTRAB9AABCG2HPGD | |
| SCHEMBL16841242 | 0.83 | KMT2A (0.46) | MAPTRAB9AHPGDNPC1SMN1; SMN2 | |
| SCHEMBL16841243 | 0.82 | TSHR (0.55) | GPR35MAPTRAB9AHPGDNPC1 | |
| SCHEMBL17943334 | 0.81 | MAPT (0.55) | MAPTRAB9AHPGDNPC1SMN1; SMN2 | |
| SCHEMBL17948846 | 0.77 | MAPT (0.55) | MAPTRAB9AHPGDNPC1SMN1; SMN2 | |
| SCHEMBL17938583 | 0.75 | MAPT (0.55) | MAPTRAB9AHPGDNPC1SMN1; SMN2 | |
| SCHEMBL17938585 | 0.74 | MAPT (0.59) | GPR35MAPTRAB9AHPGDNPC1 | |
| SCHEMBL16844437 | 0.70 | MAPT (0.66) | MAPTRAB9AHPGDNPC1SMN1; SMN2 | |
| SCHEMBL15561067 | 0.70 | F10 (0.74) | GPR35MAPTRAB9AABCG2NPC1 | |
| SCHEMBL4448025 | 0.69 | CDK7 (0.62) | MAPTRAB9AHPGDNPC1XBP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9867879-B2 | Methods for use of small molecule activators of hem-Y / protoporphyrinogen oxidase (PPO) | VANDERBILT UNIVERSITY (US) | 2018-01-16 | — | — | US | disclosed |
| US-9867879-B2 | Methods for use of small molecule activators of hem-Y / protoporphyrinogen oxidase (PPO) | VANDERBILT UNIVERSITY (US) | 2018-01-16 | — | — | US | disclosed |
| US-20170246149-A1 | COMPOSITIONS AND METHODS FOR TREATING MICROBIAL INFECTIONS | VANDERBILT UNIVERSITY | 2017-08-31 | — | — | US | disclosed |
| US-20170246149-A1 | COMPOSITIONS AND METHODS FOR TREATING MICROBIAL INFECTIONS | VANDERBILT UNIVERSITY | 2017-08-31 | — | — | US | disclosed |
| US-20160213780-A1 | METHODS FOR USE OF SMALL MOLECULE ACTIVATORS OF HEM-Y / PROTOPORPHYRINOGEN OXIDASE (PPO) | VANDERBILT UNIVERSITY | 2016-07-28 | — | — | US | disclosed |
| US-20160213780-A1 | METHODS FOR USE OF SMALL MOLECULE ACTIVATORS OF HEM-Y / PROTOPORPHYRINOGEN OXIDASE (PPO) | VANDERBILT UNIVERSITY | 2016-07-28 | — | — | US | disclosed |
| US-20150174130-A1 | COMPOSITIONS AND METHODS FOR TREATING MICROBIAL INFECTIONS | VANDERBILT UNIVERSITY | 2015-06-25 | — | — | US | disclosed |
| US-20150174130-A1 | COMPOSITIONS AND METHODS FOR TREATING MICROBIAL INFECTIONS | VANDERBILT UNIVERSITY | 2015-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160213780-A1 | METHODS FOR USE OF SMALL MOLECULE ACTIVATORS OF HEM-Y / PROTOPORPHYRINOGEN OXIDASE (PPO) | PPOX, HCCS, HMOX2 | GPR35 3313/4885MAPT 4774/4885RAB9A 1246/4885 |
| US-20150174130-A1 | COMPOSITIONS AND METHODS FOR TREATING MICROBIAL INFECTIONS | HMOX1, HMOX2, HMBS | GPR35 2988/4885MAPT 3815/4885RAB9A 1155/4885 |
| US-20170246149-A1 | COMPOSITIONS AND METHODS FOR TREATING MICROBIAL INFECTIONS | HMOX1, HMOX2, HMBS | GPR35 2988/4885MAPT 3815/4885RAB9A 1155/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.