Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.39 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.37 |
| ▸ | MEP1B | Q16820 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12641698 | 0.85 | ALDH1A1 (0.39) | ALDH1A1LMNASMN1; SMN2GAAHSD17B10 | |
| SCHEMBL1925890 | 0.83 | LMNA (0.43) | ALDH1A1LMNASMN1; SMN2GAAHSD17B10 | |
| SCHEMBL1925985 | 0.83 | ALDH1A1 (0.41) | ALDH1A1LMNASMN1; SMN2GAAHSD17B10 | |
| SCHEMBL2026104 | 0.81 | BCAT1 (0.55) | LMNAGAAKMT2AKDM4E | |
| SCHEMBL20377340 | 0.80 | ATM (0.43) | ALDH1A1SMN1; SMN2GAAHSD17B10MEP1B | |
| SCHEMBL27903861 | 0.80 | BCAT1 (0.53) | LMNAGAAKMT2AKDM4E | |
| SCHEMBL18770168 | 0.80 | SMN1; SMN2 (0.43) | ALDH1A1LMNASMN1; SMN2GAAHSD17B10 | |
| SCHEMBL27621985 | 0.79 | CA1 (0.61) | ALDH1A1GAAKMT2AMEN1 | |
| SCHEMBL15879184 | 0.75 | CA1 (0.57) | ALDH1A1LMNASMN1; SMN2GAAHSD17B10 | |
| SCHEMBL29528116 | 0.75 | CA1 (0.57) | ALDH1A1LMNASMN1; SMN2GAAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240066002-A1 | NITROXYL DONORS WITH IMPROVED THERAPEUTIC INDEX | CARDIOXYL PHARMACEUTICALS, INC. | 2024-02-29 | — | — | US | disclosed |
| US-11786501-B2 | Nitroxyl donors with improved therapeutic index | CARDIOXYL PHARMACEUTICALS, INC. (US) | 2023-10-17 | — | — | US | disclosed |
| US-9968584-B2 | Nitroxyl donors with improved therapeutic index | CARDIOXYL PHARMACEUTICALS, INC. (US) | 2018-05-15 | — | — | US | disclosed |
| US-20170151210-A1 | NITROXYL DONORS WITH IMPROVED THERAPEUTIC INDEX | CARDIOXYL PHARMACEUTICALS, INC. | 2017-06-01 | — | — | US | disclosed |
| US-9156804-B2 | Nitroxyl donors with improved therapeutic index | CARDIOXYL PHARMACEUTICALS, INC. (US) | 2015-10-13 | — | — | US | disclosed |
| US-20150175566-A1 | NITROXYL DONORS WITH IMPROVED THERAPEUTIC INDEX | CARDIOXYL PHARMACEUTICALS, INC. | 2015-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11786501-B2 | Nitroxyl donors with improved therapeutic index | TNNI3, TNNT2, TNNC1 | ALDH1A1 1005/4885LMNA 2293/4885SMN1; SMN2 339/4885 |
| US-20150175566-A1 | NITROXYL DONORS WITH IMPROVED THERAPEUTIC INDEX | TNNI3, TNNT2, TNNC1 | ALDH1A1 1005/4885LMNA 2293/4885SMN1; SMN2 339/4885 |
| US-20240066002-A1 | NITROXYL DONORS WITH IMPROVED THERAPEUTIC INDEX | TNNI3, TNNT2, TNNC1 | ALDH1A1 1005/4885LMNA 2293/4885SMN1; SMN2 339/4885 |
| US-20170151210-A1 | NITROXYL DONORS WITH IMPROVED THERAPEUTIC INDEX | TNNI3, TNNT2, TNNC1 | ALDH1A1 1005/4885LMNA 2293/4885SMN1; SMN2 339/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.