Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AMY1A | P0DUB6 | 4/20 | 0.51 |
| ▸ | PRKAB2 | O43741 | 2/20 | 0.45 |
| ▸ | PRKAG1 | P54619 | 2/20 | 0.45 |
| ▸ | PRKAA2 | P54646 | 2/20 | 0.45 |
| ▸ | PRKAA1 | Q13131 | 2/20 | 0.45 |
| ▸ | PRKAG3 | Q9UGI9 | 2/20 | 0.45 |
| ▸ | PRKAG2 | Q9UGJ0 | 2/20 | 0.45 |
| ▸ | PRKAB1 | Q9Y478 | 2/20 | 0.45 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.43 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.42 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.39 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14648802 | 0.87 | CYP11B1 (0.43) | AMY1ACD274CYP11B1CYP11B2NPC1 | |
| SCHEMBL10340365 | 0.84 | AMY1A (0.50) | AMY1APRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL16855942 | 0.82 | CA12 (0.48) | AMY1AGRM2PRKCZCD274ERN1 | |
| SCHEMBL16852406 | 0.81 | HMOX1 (0.43) | AMY1APRKCZCYP1A2NPC1 | |
| SCHEMBL16855819 | 0.81 | ERN1 (0.46) | AMY1APRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL16852416 | 0.79 | ACACB (0.41) | NPC1RAB9A | |
| SCHEMBL16852412 | 0.79 | MEN1 (0.41) | NPC1RAB9A | |
| SCHEMBL18436302 | 0.79 | CD274 (0.48) | AMY1AGRM2CD274ERN1GPR35 | |
| SCHEMBL1528920 | 0.79 | CD274 (0.48) | AMY1APRKAB2PRKAG1PRKAA2PRKAA1 | |
| SCHEMBL171839 | 0.78 | CYP1A2 (0.47) | AMY1ACYP1A2CYP1A1CYP1B1CYP2A6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9951274-B2 | Liquid-crystalline medium | MERCK PATENT GMBH (DE) | 2018-04-24 | — | — | US | disclosed |
| US-20170362506-A1 | LIQUID-CRYSTALLINE MEDIUM | MERCK PATENT GMBH (DE) | 2017-12-21 | — | — | US | disclosed |
| US-20170044438-A1 | LIQUID-CRYSTALLINE MEDIUM | MERCK PATENT GMBH (DE) | 2017-02-16 | — | — | US | disclosed |
| US-20170044437-A1 | LIQUID-CRYSTALLINE MEDIUM | MERCK PATENT GMBH (DE) | 2017-02-16 | — | — | US | disclosed |
| US-20160319194-A1 | LIQUID CRYSTALLINE MEDIUM | MERCK PATENT GMBH (DE) | 2016-11-03 | — | — | US | disclosed |
| US-20160152587-A1 | LIQUID-CRYSTALLINE MEDIUM | MERCK PATENT GMBH (DE) | 2016-06-02 | — | — | US | disclosed |
| US-20150299574-A1 | LIQUID CRYSTALLINE MEDIUM | MERCK PATENT GMBH (DE) | 2015-10-22 | — | — | US | disclosed |
| US-20150175884-A1 | LIQUID-CRYSTALLINE MEDIUM | MERCK PATENT GMBH (DE) | 2015-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170044438-A1 | LIQUID-CRYSTALLINE MEDIUM | VIM, COL2A1, COL1A1 | AMY1A 667/4885PRKAB2 3282/4885PRKAG1 2834/4885 |
| US-20170044437-A1 | LIQUID-CRYSTALLINE MEDIUM | VIM, COL2A1, COL1A1 | AMY1A 667/4885PRKAB2 3282/4885PRKAG1 2834/4885 |
| US-20160152587-A1 | LIQUID-CRYSTALLINE MEDIUM | VIM, COL2A1, COL1A1 | AMY1A 667/4885PRKAB2 3282/4885PRKAG1 2834/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.