Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.72 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | GAA | P10253 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | JAK3 | P52333 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | OGA | O60502 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | F10 | P00742 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18175699 | 0.82 | ALDH1A1 (0.65) | ALDH1A1LMNAGAARECQLKMT2A | |
| SCHEMBL16854335 | 0.80 | ALDH1A1 (0.71) | ALDH1A1LMNAGAARECQLKMT2A | |
| SCHEMBL486699 | 0.80 | ALDH1A1 (0.66) | ALDH1A1LMNAGAARECQLKMT2A | |
| SCHEMBL4590541 | 0.78 | ALDH1A1 (0.64) | ALDH1A1LMNAGAARECQLKMT2A | |
| SCHEMBL27814718 | 0.77 | ALDH1A1 (0.62) | ALDH1A1LMNAGAARECQLKMT2A | |
| SCHEMBL3085138 | 0.77 | ALDH1A1 (0.67) | ALDH1A1LMNAGAARECQLKMT2A | |
| SCHEMBL30664796 | 0.76 | ALDH1A1 (0.57) | ALDH1A1LMNAGAARECQLKMT2A | |
| SCHEMBL12079342 | 0.75 | ALDH1A1 (0.60) | ALDH1A1LMNAGAARECQLKMT2A | |
| SCHEMBL16854349 | 0.71 | ACHE (0.62) | ALDH1A1LMNARECQLKMT2A | |
| SCHEMBL14132153 | 0.71 | LMNA (1.00) | ALDH1A1LMNAGAARECQLKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3085701-B1 | N, N' SUBSTITUTED PIPERIDINAMINE COMPOUNDS, AND PREPARATION METHOD AND USAGE THEREOF | INST PHARMACOLOGY & TOXICOLOGY ACADEMY MILITARY MEDICAL SCIENCES PLA CHINA (CN) | 2019-02-20 | — | — | EP | disclosed |
| US-10023565-B2 | N,N′ substituted piperidinamine compounds, and preparation method and usage thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2018-07-17 | — | — | US | disclosed |
| US-10023565-B2 | N,N′ substituted piperidinamine compounds, and preparation method and usage thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2018-07-17 | — | — | US | disclosed |
| US-10023565-B2 | N,N′ substituted piperidinamine compounds, and preparation method and usage thereof | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2018-07-17 | — | — | US | disclosed |
| US-20160333002-A1 | N, N' SUBSTITUTED PIPERIDINAMINE COMPOUNDS, AND PREPARATION METHOD AND USAGE THEREOF | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2016-11-17 | — | — | US | disclosed |
| US-20160333002-A1 | N, N' SUBSTITUTED PIPERIDINAMINE COMPOUNDS, AND PREPARATION METHOD AND USAGE THEREOF | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2016-11-17 | — | — | US | disclosed |
| US-20160333002-A1 | N, N' SUBSTITUTED PIPERIDINAMINE COMPOUNDS, AND PREPARATION METHOD AND USAGE THEREOF | INSTITUTE OF PHARMACOLOGY AND TOXICOLOGY ACADEMY OF MILITARY MEDICAL SCIENCES P.L.A. CHINA (CN) | 2016-11-17 | — | — | US | disclosed |
| EP-3085701-A1 | N, N' SUBSTITUTED PIPERIDINAMINE COMPOUNDS, AND PREPARATION METHOD AND USAGE THEREOF | Institute of Pharmacology and Toxicology Academy of Military Medical Sciences P.L.A. China (CN) | 2016-10-26 | — | — | EP | disclosed |
| CN-105829304-A | N, n substituted piperidinamine compounds, and preparation method and usage thereof | 中国人民解放军军事医学科学院毒物药物研究所 | 2016-08-03 | — | — | CN | disclosed |
| WO-2015090226-A1 | N, N' SUBSTITUTED PIPERIDINAMINE COMPOUNDS, AND PREPARATION METHOD AND USAGE THEREOF | 中国人民解放军军事医学科学院毒物药物研究所 | 2015-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10023565-B2 | N,N′ substituted piperidinamine compounds, and preparation method and usage thereof | HSP90AB1, HSP90AB2P, HSF1 | ALDH1A1 863/4885LMNA 3093/4885GAA 2102/4885 |
| US-20160333002-A1 | N, N' SUBSTITUTED PIPERIDINAMINE COMPOUNDS, AND PREPARATION METHOD AND USAGE THEREOF | HSP90AB1, HSP90AB2P, HSF1 | ALDH1A1 823/4885LMNA 3221/4885GAA 2180/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.