Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G2A | P14555 | 6/20 | 0.50 |
| ▸ | PLA2G10 | O15496 | 4/20 | 0.50 |
| ▸ | PLA2G1B | P04054 | 3/20 | 0.50 |
| ▸ | PLA2G5 | P39877 | 3/20 | 0.50 |
| ▸ | KIF11 | P52732 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TK1 | P04183 | 2/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TK2 | O00142 | 1/20 | 0.32 |
| ▸ | PPARD | Q03181 | 1/20 | 0.32 |
| ▸ | LTA4H | P09960 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18912718 | 0.88 | PLA2G2A (0.55) | PLA2G2APLA2G10PLA2G1BPLA2G5KIF11 | |
| SCHEMBL8357825 | 0.83 | PLA2G2A (0.59) | PLA2G2APLA2G10PLA2G1BPLA2G5KIF11 | |
| SCHEMBL16826862 | 0.82 | CA1 (0.36) | PLA2G2APLA2G10PLA2G1BPLA2G5KIF11 | |
| SCHEMBL8979451 | 0.80 | PLA2G2A (0.54) | PLA2G2APLA2G10PLA2G1BPLA2G5KIF11 | |
| SCHEMBL18609340 | 0.80 | PLA2G2A (0.49) | PLA2G2APLA2G10PLA2G1BPLA2G5KIF11 | |
| SCHEMBL8357808 | 0.80 | PLA2G2A (0.49) | PLA2G2APLA2G10PLA2G1BPLA2G5TK1 | |
| SCHEMBL8352756 | 0.80 | PLA2G2A (0.49) | PLA2G2APLA2G10PLA2G1BPLA2G5TK1 | |
| SCHEMBL8353085 | 0.80 | PLA2G2A (0.49) | PLA2G2APLA2G10PLA2G1BPLA2G5TK1 | |
| SCHEMBL8741371 | 0.80 | PLA2G2A (0.49) | PLA2G2APLA2G10PLA2G1BPLA2G5TK1 | |
| SCHEMBL8193378 | 0.80 | PLA2G2A (0.49) | PLA2G2APLA2G10PLA2G1BPLA2G5TK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170066782-A1 | DERIVATIVES OF 6-(2,3-DICHLOROPHENYL)-1,2,4-TRIAZIN-5-AMINE | NEKTAR THERAPEUTICS | 2017-03-09 | — | — | US | disclosed |
| WO-2015092819-A2 | DERIVATIVES OF 6-(2,3-DICHLOROPHENYL)-1,2,4-TRIAZIN-5- AMINE | NEKTAR THERAPEUTICS (INDIA) PVT. LTD. (IN) | 2015-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170066782-A1 | DERIVATIVES OF 6-(2,3-DICHLOROPHENYL)-1,2,4-TRIAZIN-5-AMINE | KCNJ2, TRPC5, RYR2 | PLA2G2A 3284/4885PLA2G10 3651/4885PLA2G1B 3066/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.