Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 9/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 8/20 | 0.50 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.45 |
| ▸ | DUSP3 | P51452 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.42 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.41 |
| ▸ | RXRA | P19793 | 1/20 | 0.40 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2564471 | 0.86 | PTPN1 (0.61) | ALOX5APALOX5PTPN1DUSP3ALDH1A1 | |
| SCHEMBL1686554 | 0.85 | PTPN1 (0.45) | ALOX5APALOX5PTPN1DUSP3SMN1; SMN2 | |
| SCHEMBL1686474 | 0.85 | PTPN1 (0.45) | ALOX5APALOX5PTPN1DUSP3SMN1; SMN2 | |
| SCHEMBL1686323 | 0.85 | KMO (0.45) | PTPN1DUSP3RXRA | |
| SCHEMBL2490559 | 0.83 | DUSP3 (0.53) | PTPN1DUSP3TRPV1RXRANR4A2 | |
| SCHEMBL1686288 | 0.82 | TRPV1 (0.56) | TRPV1 | |
| SCHEMBL1686250 | 0.80 | ALOX5 (0.53) | ALOX5APALOX5PTPN1DUSP3SMN1; SMN2 | |
| SCHEMBL1686287 | 0.80 | TRPV1 (0.48) | ALOX5APALOX5PTPN1SMN1; SMN2TRPV1 | |
| SCHEMBL1686351 | 0.80 | PTPN1 (0.51) | ALOX5APALOX5PTPN1DUSP3SMN1; SMN2 | |
| SCHEMBL1686357 | 0.77 | ALOX5AP (0.49) | ALOX5APALOX5PTPN1DUSP3SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8211927-B2 | 5-phenyl-isoxazole-3-carboxamide derivatives as TRPV1 modulators | MSD, Oss B.V. (NL) | 2012-07-03 | — | — | US | disclosed |
| EP-2185530-B1 | 5-PHENYL-ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES AS TRPV1 MODULATORS | ORGANON NV (NL) | 2011-09-14 | — | — | EP | disclosed |
| US-20110065764-A1 | 5- PHENYL-ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES AS TRPV1 MODULATORS | N.V. Organon and Pharmacopeia, LLC (NL) | 2011-03-17 | — | — | US | disclosed |
| US-4322429-A | Isoxazolylbenzamides as insecticides | ELI LILLY AND COMPANY (US) | 1982-03-30 | — | — | US | disclosed |
| EP-0048162-A1 | Isoxazolylbenzamides | ELI LILLY AND COMPANY (US) | 1982-03-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065764-A1 | 5- PHENYL-ISOXAZOLE-3-CARBOXAMIDE DERIVATIVES AS TRPV1 MODULATORS | TRPV1, TRPV5, TRPV3 | ALOX5AP 380/4885ALOX5 431/4885PTPN1 1569/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.