Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 8/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 7/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.47 |
| ▸ | GABRG2 | P18507 | 7/20 | 0.47 |
| ▸ | GABRB3 | P28472 | 7/20 | 0.47 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.47 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.47 |
| ▸ | GABRA4 | P48169 | 7/20 | 0.47 |
| ▸ | GABRA6 | Q16445 | 7/20 | 0.47 |
| ▸ | GABRP | O00591 | 6/20 | 0.47 |
| ▸ | GABRD | O14764 | 6/20 | 0.47 |
| ▸ | GABRB1 | P18505 | 6/20 | 0.47 |
| ▸ | GABRE | P78334 | 6/20 | 0.47 |
| ▸ | GABRG1 | Q8N1C3 | 6/20 | 0.47 |
| ▸ | GABRG3 | Q99928 | 6/20 | 0.47 |
| ▸ | GABRQ | Q9UN88 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24572143 | 0.84 | GABRA2 (0.53) | CYP1A2GABRA2GABRB2MAPTKDM4E | |
| SCHEMBL127699 | 0.83 | CYP1A2 (0.53) | CYP1A2TSHRGABRA2GABRB2GABRA1 | |
| SCHEMBL30234144 | 0.81 | CA12 (0.51) | CYP1A2GABRA2GABRB2GABRA1GABRG2 | |
| SCHEMBL29466587 | 0.81 | JMJD6 (0.57) | CYP1A2GABRA2GABRB2GABRA1GABRG2 | |
| SCHEMBL30440953 | 0.81 | CYP1A2 (0.51) | CYP1A2GABRA2GABRB2GABRA1GABRG2 | |
| SCHEMBL159881 | 0.81 | CYP1A2 (0.51) | CYP1A2TSHRGABRA2GABRB2GABRA1 | |
| SCHEMBL930636 | 0.81 | JMJD6 (0.57) | CYP1A2GABRA2GABRB2GABRA1GABRG2 | |
| SCHEMBL5778009 | 0.81 | CA12 (0.51) | CYP1A2GABRA2GABRB2GABRA1GABRG2 | |
| SCHEMBL2305000 | 0.81 | ALDH1A1 (0.50) | CYP1A2GABRA2GABRB2GABRA1GABRG2 | |
| SCHEMBL30945316 | 0.81 | ALDH1A1 (0.50) | CYP1A2GABRA2GABRB2GABRA1GABRG2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150225404-A1 | PYRIDINE DERIVATIVE AND MEDICINE | NIPPON SHINYAKU CO., LTD. (JP) | 2015-08-13 | — | — | US | disclosed |
| EP-2891656-A1 | PYRIDINE DERIVATIVE AND MEDICINE | Nippon Shinyaku Co., Ltd. (JP) | 2015-07-08 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225404-A1 | PYRIDINE DERIVATIVE AND MEDICINE | TRPV1, TRPV5, TRPM5 | CYP1A2 2274/4885TSHR 894/4885GABRA2 375/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.