Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAB1 | Q13480 | 1/20 | 0.45 |
| ▸ | MMP8 | P22894 | 2/20 | 0.42 |
| ▸ | MMP3 | P08254 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 5/20 | 0.40 |
| ▸ | ACLY | P53396 | 2/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21067285 | 0.80 | ACLY (0.54) | GAB1ACLY | |
| SCHEMBL4316537 | 0.79 | GAB1 (0.44) | GAB1MMP8MMP3CA2HTR6 | |
| SCHEMBL14087505 | 0.78 | GAB1 (0.51) | GAB1MMP8MMP3CA2HTR6 | |
| SCHEMBL15880546 | 0.77 | CA2 (0.52) | GAB1MMP8MMP3CA2HTR6 | |
| SCHEMBL3556126 | 0.75 | MEN1 (0.47) | GAB1ACLYALDH1A1SMN1; SMN2 | |
| SCHEMBL13633850 | 0.74 | SLC40A1 (0.65) | ALDH1A1 | |
| SCHEMBL3552834 | 0.73 | MEN1 (0.45) | GAB1ACLYSMN1; SMN2 | |
| SCHEMBL7460372 | 0.73 | HTR6 (0.56) | GAB1MMP8MMP3CA2HTR6 | |
| SCHEMBL3557735 | 0.72 | SLC16A3 (0.45) | GAB1ACLYSMN1; SMN2 | |
| SCHEMBL3558197 | 0.72 | SLC16A3 (0.60) | GAB1ACLY |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2484680-A1 | Useful Combinations of Monobactam Antibiotics with beta-Lac-tamase Inhibitors | Basilea Pharmaceutica AG (CH) | 2012-08-08 | — | — | EP | disclosed |
| EP-2308874-A1 | Useful beta-lactamase inhibitors | Basilea Pharmaceutica AG (CH) | 2011-04-13 | — | — | EP | disclosed |