Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 2/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | CA2 | P00918 | 2/20 | 0.42 |
| ▸ | CA9 | Q16790 | 2/20 | 0.42 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 8/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8511034 | 0.86 | MAPT (0.49) | KMT2ASMN1; SMN2MEN1ALDH1A1MAPT | |
| SCHEMBL31191034 | 0.85 | CRHBP (0.39) | CYP19A1KMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL31290998 | 0.85 | CRHBP (0.39) | CYP19A1KMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL15549951 | 0.81 | MAPT (0.41) | CA12CA1CA2CA9CYP19A1 | |
| SCHEMBL18973787 | 0.80 | CYP19A1 (0.41) | CYP19A1KMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL25359757 | 0.80 | CYP19A1 (0.58) | CYP19A1KMT2ASMN1; SMN2MEN1MAPT | |
| SCHEMBL25357971 | 0.80 | CYP19A1 (0.39) | CYP19A1KMT2ASMN1; SMN2MEN1ALDH1A1 | |
| SCHEMBL25357966 | 0.80 | ALDH1A1 (0.40) | CYP19A1KMT2AMEN1ALDH1A1MAPT | |
| SCHEMBL8512483 | 0.74 | KMT2A (0.45) | CYP19A1KMT2ASMN1; SMN2ALDH1A1MAPT | |
| SCHEMBL30623145 | 0.74 | KMT2A (0.45) | CYP19A1KMT2ASMN1; SMN2ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118973616-A | Trkb ligand conjugated compounds and uses thereof | 阿达尔克斯制药有限公司 | 2024-11-15 | — | — | CN | disclosed |
| US-10596145-B2 | Heterocyclic flavone derivatives, compositions, and methods related thereto | EMORY UNIVERSITY (US) | 2020-03-24 | — | — | US | disclosed |
| US-20190160040-A1 | Heterocyclic Flavone Derivatives, Compositions, and Methods Related Thereto | UNIV EMORY (US) | 2019-05-30 | — | — | US | disclosed |
| US-20180280342-A1 | Heterocyclic Flavone Derivatives, Compositions, and Methods Related Thereto | UNIV EMORY (US) | 2018-10-04 | — | — | US | disclosed |
| US-10010526-B2 | Heterocyclic flavone derivatives, compositions, and methods related thereto | EMORY UNIVERSITY (US) | 2018-07-03 | — | — | US | disclosed |
| US-20170165225-A1 | Heterocyclic Flavone Derivatives, Compositions, and Methods Related Thereto | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-06-15 | — | — | US | disclosed |
| US-20170165225-A1 | Heterocyclic Flavone Derivatives, Compositions, and Methods Related Thereto | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2017-06-15 | — | — | US | disclosed |
| US-9593125-B2 | Heterocyclic flavone derivatives, compositions, and methods related thereto | EMORY UNIVERSITY (US) | 2017-03-14 | — | — | US | disclosed |
| US-20150191481-A1 | HETEROCYCLIC FLAVONE DERIVATIVES, COMPOSITIONS, AND METHODS RELATED THERETO | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2015-07-09 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180280342-A1 | Heterocyclic Flavone Derivatives, Compositions, and Methods Related Thereto | BDNF, NTRK2, RHOT2 | MDM2 314/4885CA12 4800/4885CA1 2431/4885 |
| US-10010526-B2 | Heterocyclic flavone derivatives, compositions, and methods related thereto | BDNF, NTRK2, RHOT2 | MDM2 314/4885CA12 4800/4885CA1 2431/4885 |
| US-20170165225-A1 | Heterocyclic Flavone Derivatives, Compositions, and Methods Related Thereto | BDNF, NTRK2, RHOT2 | MDM2 314/4885CA12 4800/4885CA1 2431/4885 |
| US-10596145-B2 | Heterocyclic flavone derivatives, compositions, and methods related thereto | BDNF, NTRK2, RHOT2 | MDM2 314/4885CA12 4800/4885CA1 2431/4885 |
| US-20190160040-A1 | Heterocyclic Flavone Derivatives, Compositions, and Methods Related Thereto | BDNF, NTRK2, RHOT2 | MDM2 314/4885CA12 4800/4885CA1 2431/4885 |
| US-20150191481-A1 | HETEROCYCLIC FLAVONE DERIVATIVES, COMPOSITIONS, AND METHODS RELATED THERETO | BDNF, NTRK2, RHOT2 | MDM2 308/4885CA12 4768/4885CA1 2251/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.