Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 4/20 | 0.69 |
| ▸ | BACE1 | P56817 | 3/20 | 0.66 |
| ▸ | APP | P05067 | 6/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.60 |
| ▸ | TTR | P02766 | 3/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.59 |
| ▸ | TSHR | P16473 | 3/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.59 |
| ▸ | MAPT | P10636 | 3/20 | 0.59 |
| ▸ | MMP9 | P14780 | 3/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.59 |
| ▸ | DPP4 | P27487 | 2/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.59 |
| ▸ | CA12 | O43570 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | CA1 | P00915 | 2/20 | 0.59 |
| ▸ | CA2 | P00918 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Didemethylcurcumin SCHEMBL613667 | 0.90 | IAPP (0.77) | IAPPBACE1APPPTGS1TTR | |
| Didemethylcurcumin SCHEMBL613666 | 0.90 | IAPP (0.77) | IAPPBACE1APPPTGS1TTR | |
| SCHEMBL16093012 | 0.87 | IAPP (0.64) | IAPPBACE1APPPTGS1TTR | |
| SCHEMBL14259638 | 0.86 | IAPP (0.63) | IAPPBACE1APPPTGS1TTR | |
| SCHEMBL14259636 | 0.86 | BACE1 (0.65) | IAPPBACE1APPPTGS1TTR | |
| SCHEMBL4005096 | 0.85 | IAPP (0.71) | IAPPBACE1APPPTGS1TTR | |
| SCHEMBL4005087 | 0.85 | IAPP (0.71) | IAPPBACE1APPPTGS1TTR | |
| SCHEMBL8965104 | 0.85 | BACE1 (0.88) | IAPPBACE1APPPTGS1HSD17B10 | |
| SCHEMBL8965107 | 0.85 | BACE1 (0.88) | IAPPBACE1APPPTGS1HSD17B10 | |
| SCHEMBL23367866 | 0.84 | BACE1 (0.59) | IAPPBACE1APPPTGS1TTR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180221514-A1 | NITROXIDE CONTAINING AMYLOID BINDING AGENTS FOR IMAGING AND THERAPEUTIC USES | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2018-08-09 | — | — | US | disclosed |
| US-9074238-B2 | Methods for enhancing neprilysin activity and degrading amyloid-beta peptides and oligomers in a subject with Alzheimer's disease | ACADEMIA SINICA (TW) | 2015-07-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180221514-A1 | NITROXIDE CONTAINING AMYLOID BINDING AGENTS FOR IMAGING AND THERAPEUTIC USES | APP, APBA1, CRYAB | IAPP 16/4885BACE1 12/4885APP 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.