Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TGFBR1 | P36897 | 7/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.33 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.33 |
| ▸ | ACVR1B | P36896 | 1/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CCR2 | P41597 | 1/20 | 0.32 |
| ▸ | CCR9 | P51686 | 1/20 | 0.32 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.32 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16888488 | 0.85 | TGFBR1 (0.58) | TGFBR1BMPR1AACVR1BACVRL1ACVR1 | |
| SCHEMBL16888489 | 0.83 | TGFBR1 (0.55) | TGFBR1CYP3A4BMPR1AACVR1BACVRL1 | |
| SCHEMBL18219788 | 0.79 | MAPK14 (0.35) | TGFBR1ALDH1A1MAPK14CYP3A4BMPR1A | |
| SCHEMBL18219787 | 0.74 | NUDT1 (0.47) | TGFBR1BMPR1AACVR1BACVRL1ACVR1 | |
| SCHEMBL18221548 | 0.72 | TGFBR1 (0.48) | TGFBR1CYP3A4BMPR1AACVR1BACVRL1 | |
| SCHEMBL22270337 | 0.64 | TGFBR1 (0.79) | TGFBR1CYP3A4BMPR1AACVR1BACVRL1 | |
| SCHEMBL30294397 | 0.61 | KDM4E (0.54) | ALDH1A1KDM4EMAPK14 | |
| SCHEMBL22852993 | 0.61 | KDM4E (0.54) | ALDH1A1KDM4EMAPK14 | |
| SCHEMBL30564933 | 0.61 | ALDH1A1 (0.56) | ALDH1A1KDM4EGLAGAASMN1; SMN2 | |
| SCHEMBL910922 | 0.61 | ALDH1A1 (0.56) | ALDH1A1KDM4EGLAGAASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015103355-A1 | COMPOUNDS AND METHODS OF USE | MEDIVATION TECHNOLOGIES, INC. (US) | 2015-07-09 | — | — | WO | disclosed |