Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 5/20 | 0.39 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.38 |
| ▸ | IL4I1 | Q96RQ9 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL118612 | 0.88 | OPRM1 (0.44) | OPRM1OPRL1IL4I1 | |
| SCHEMBL6180992 | 0.83 | ALDH1A1 (0.42) | OPRM1OPRL1IL4I1 | |
| SCHEMBL3237390 | 0.81 | OPRM1 (0.40) | OPRM1 | |
| SCHEMBL3270477 | 0.77 | OPRM1 (0.40) | OPRM1 | |
| SCHEMBL625655 | 0.77 | OPRM1 (0.40) | OPRM1 | |
| SCHEMBL2131500 | 0.77 | OPRM1 (0.58) | OPRM1 | |
| SCHEMBL3903587 | 0.77 | OPRM1 (0.40) | OPRM1 | |
| SCHEMBL625403 | 0.77 | OPRM1 (0.58) | OPRM1OPRL1 | |
| SCHEMBL13594179 | 0.77 | OPRM1 (0.60) | OPRM1 | |
| SCHEMBL626037 | 0.77 | OPRM1 (0.51) | OPRM1OPRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3092239-B1 | ARYL SULTAM DERIVATIVES AS RORC MODULATORS | HOFFMANN LA ROCHE (CH) | 2019-10-02 | — | — | EP | disclosed |
| EP-3092239-B1 | ARYL SULTAM DERIVATIVES AS RORC MODULATORS | HOFFMANN LA ROCHE (CH) | 2019-10-02 | — | — | EP | disclosed |
| CN-105899507-B | Aryl sultam derivative as RORc regulator | 豪夫迈·罗氏有限公司 | 2019-06-07 | — | — | CN | disclosed |
| US-10131644-B2 | Aryl sultam derivatives as RORc modulators | GENENTECH, INC. (US) | 2018-11-20 | — | — | US | disclosed |
| US-20170137393-A1 | ARYL SULTAM DERIVATIVES AS RORc MODULATORS | GENENTECH, INC. (US) | 2017-05-18 | — | — | US | disclosed |
| US-20170137393-A1 | ARYL SULTAM DERIVATIVES AS RORc MODULATORS | GENENTECH, INC. (US) | 2017-05-18 | — | — | US | disclosed |
| US-20170137393-A1 | ARYL SULTAM DERIVATIVES AS RORc MODULATORS | GENENTECH, INC. (US) | 2017-05-18 | — | — | US | disclosed |
| EP-3092239-A1 | ARYL SULTAM DERIVATIVES AS RORc MODULATORS | F. Hoffmann-La Roche AG (CH) | 2016-11-16 | — | — | EP | disclosed |
| CN-105899507-A | Aryl sultam derivatives as rorc modulators | 豪夫迈·罗氏有限公司 | 2016-08-24 | — | — | CN | disclosed |
| WO-2015104354-A1 | ARYL SULTAM DERIVATIVES AS RORc MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-07-16 | — | — | WO | disclosed |
| WO-2015104354-A1 | ARYL SULTAM DERIVATIVES AS RORc MODULATORS | F. HOFFMANN-LA ROCHE AG (CH) | 2015-07-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10131644-B2 | Aryl sultam derivatives as RORc modulators | RORC, RORB, RORA | OPRM1 56/4885OPRL1 521/4885IL4I1 994/4885 |
| US-20170137393-A1 | ARYL SULTAM DERIVATIVES AS RORc MODULATORS | RORC, RORB, RORA | OPRM1 56/4885OPRL1 521/4885IL4I1 994/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.