Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 2/20 | 0.50 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.44 |
| ▸ | GPR35 | Q9HC97 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | TTR | P02766 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL69389 | 0.84 | ALDH1A1 (0.60) | MEN1KMT2AHTTLMNAALDH1A1 | |
| SCHEMBL309438 | 0.84 | CYP19A1 (0.62) | MEN1KMT2AHTTLMNAALDH1A1 | |
| SCHEMBL593064 | 0.84 | CYP19A1 (0.62) | MEN1KMT2AHTTLMNAALDH1A1 | |
| SCHEMBL9265700 | 0.84 | ALDH1A1 (0.60) | MEN1KMT2AHTTLMNAALDH1A1 | |
| SCHEMBL222935 | 0.84 | LMNA (0.56) | MEN1KMT2AHTTLMNAALDH1A1 | |
| Water SCHEMBL28180935 | 0.81 | CYP19A1 (0.59) | MEN1KMT2AHTTLMNAALDH1A1 | |
| SCHEMBL30387741 | 0.81 | CYP19A1 (0.59) | MEN1KMT2AHTTLMNAALDH1A1 | |
| SCHEMBL29381787 | 0.81 | CYP19A1 (0.59) | MEN1KMT2AHTTLMNAALDH1A1 | |
| SCHEMBL1171962 | 0.74 | LMNA (0.47) | MEN1KMT2AHTTLMNAALDH1A1 | |
| SCHEMBL220173 | 0.74 | LMNA (0.47) | MEN1KMT2AHTTLMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102653511-A | 3,5-diaryl benzene ring ether derivate as well as preparation method and application thereof | SHANGHAI KAIYOU FINE CHEMICAL CO LTD | 2012-09-05 | — | — | CN | claimed |
| CN-102653511-A | 3,5-diaryl benzene ring ether derivate as well as preparation method and application thereof | SHANGHAI KAIYOU FINE CHEMICAL CO LTD | 2012-09-05 | — | — | CN | disclosed |
| CN-102653511-A | 3,5-diaryl benzene ring ether derivate as well as preparation method and application thereof | SHANGHAI KAIYOU FINE CHEMICAL CO LTD | 2012-09-05 | — | — | CN | disclosed |
| US-8093385-B2 | Leukotriene B4 inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2012-01-10 | — | — | US | disclosed |
| US-8093385-B2 | Leukotriene B4 inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2012-01-10 | — | — | US | disclosed |
| US-8093385-B2 | Leukotriene B4 inhibitors | HOFFMANN-LA ROCHE INC. (US) | 2012-01-10 | — | — | US | disclosed |
| CN-101821226-A | Leukotriene b4 inhibitors | HOFFMANN LA ROCHE | 2010-09-01 | — | — | CN | disclosed |
| EP-2190808-A1 | LEUKOTRIENE B4 INHIBITORS | F. Hoffmann-Roche AG (CH) | 2010-06-02 | — | — | EP | disclosed |
| WO-2009024492-A1 | LEUKOTRIENE B4 INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-02-26 | — | — | WO | disclosed |
| US-20090054466-A1 | Leukotriene B4 Inhibitors | DOMINIQUE ROMYR | 2009-02-26 | — | — | US | disclosed |
| US-20090054466-A1 | Leukotriene B4 Inhibitors | DOMINIQUE ROMYR | 2009-02-26 | — | — | US | disclosed |
| US-20090054466-A1 | Leukotriene B4 Inhibitors | DOMINIQUE ROMYR | 2009-02-26 | — | — | US | disclosed |
| US-6458935-B1 | LABEL FPTASE IN ASSAYS, WHETHER CELL-BASED, TISSUE-BASED OR IN WHOLE ANIMAL. THE TRACERS CAN ALSO BE USED IN COMPETITIVE BINDING ASSAYS TO OBTAIN INFORMATION ON THE INTERACTION OF UNLABELED FTIS WITH FPTASE. | MERCK & CO., INC. | 2002-10-01 | — | — | US | disclosed |
| WO-2000078363-A1 | RADIOLABELED FARNESYL-PROTEIN TRANSFERASE INHIBITORS | MERCK & CO., INC. (US) | 2000-12-28 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090054466-A1 | Leukotriene B4 Inhibitors | LTB4R2, LTB4R, LTC4S | MEN1 4324/4885KMT2A 4432/4885HTT 4597/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.