⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16900396 | 0.86 | — | — | |
| SCHEMBL13901974 | 0.84 | CYP3A4 (0.31) | — | |
| SCHEMBL14319829 | 0.84 | CYP3A4 (0.31) | — | |
| SCHEMBL18819939 | 0.84 | CYP3A4 (0.31) | — | |
| SCHEMBL14693191 | 0.82 | CPB2 (0.31) | — | |
| SCHEMBL1117817 | 0.81 | SLC15A1 (0.33) | — | |
| SCHEMBL15314080 | 0.81 | CYP3A4 (0.31) | — | |
| SCHEMBL16280971 | 0.81 | CYP3A4 (0.31) | — | |
| SCHEMBL15292000 | 0.81 | SLC15A1 (0.40) | — | |
| SCHEMBL13270040 | 0.80 | OPRM1 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9517273-B2 | Methods of treatment using modified FGF-21 polypeptides comprising non-naturally occurring amino acids | AMBRX, INC. (US) | 2016-12-13 | — | — | US | disclosed |
| US-20150273075-A1 | THERAPEUTIC USES OF MODIFIED FGF-21 POLYPEPTIDES COMPRISING NON-NATURALLY OCCURRING AMINO ACIDS | AMBRX, INC. | 2015-10-01 | — | — | US | disclosed |
| US-9079971-B2 | Modified FGF-21 polypeptides comprising non-naturally occurring amino acids | AMBRX, INC. (US) | 2015-07-14 | — | — | US | disclosed |