Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | CA2 | P00918 | 2/20 | 0.55 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.55 |
| ▸ | CA12 | O43570 | 1/20 | 0.55 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.55 |
| ▸ | CA7 | P43166 | 1/20 | 0.55 |
| ▸ | CA9 | Q16790 | 1/20 | 0.55 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | KDR | P35968 | 2/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.52 |
| ▸ | TNF | P01375 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26979278 | 0.80 | AKR1C2 (0.44) | PTGS2KDM4ECYP3A4 | |
| SCHEMBL2348838 | 0.80 | PTGS2 (0.44) | PTGS2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL1633725 | 0.78 | RXRB (0.46) | PTGS2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL21814272 | 0.78 | KEAP1 (0.58) | PTGS2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL23141189 | 0.78 | PTGS2 (0.43) | CA1CA2PTGS2CA12CA7 | |
| SCHEMBL22628276 | 0.76 | AKR1C2 (0.44) | CA1CA2PTGS2CA12CA7 | |
| SCHEMBL2342293 | 0.74 | TSHR (0.57) | CA1CA2PTGS2CA12CA7 | |
| SCHEMBL1194182 | 0.74 | ALDH1A1 (0.53) | PTGS2KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL31046834 | 0.74 | WDR5 (0.40) | PTGS2ALDH1A1HPGDHSD17B10 | |
| SCHEMBL15123097 | 0.74 | ALDH1A1 (0.49) | CA1CA2PTGS2CA12CA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015109013-A1 | DEUTERATED NO-RELEASING NITROOXY-CHROMENE CONJUGATES | Euclises Pharmaceuticals, Inc. (US) | 2015-07-23 | — | — | WO | disclosed |
| WO-2015109013-A1 | DEUTERATED NO-RELEASING NITROOXY-CHROMENE CONJUGATES | Euclises Pharmaceuticals, Inc. (US) | 2015-07-23 | — | — | WO | disclosed |
| WO-2015109017-A2 | DEUTERATED NO-RELEASING NONOATE(OXYGEN-BOUND)CHROMENE CONJUGATES | Euclises Pharmaceuticals, Inc. (US) | 2015-07-23 | — | — | WO | disclosed |
| WO-2015109017-A2 | DEUTERATED NO-RELEASING NONOATE(OXYGEN-BOUND)CHROMENE CONJUGATES | Euclises Pharmaceuticals, Inc. (US) | 2015-07-23 | — | — | WO | disclosed |