Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRB | P28702 | 2/20 | 0.46 |
| ▸ | RXRA | P19793 | 1/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.43 |
| ▸ | AKR1C3 | P42330 | 4/20 | 0.43 |
| ▸ | AKR1C2 | P52895 | 4/20 | 0.43 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.43 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.43 |
| ▸ | RARB | P10826 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | MYC | P01106 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | GABRP | O00591 | 1/20 | 0.38 |
| ▸ | GABRD | O14764 | 1/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.38 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.38 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.38 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.38 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.38 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.38 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2348838 | 0.86 | PTGS2 (0.44) | PTGS2AKR1C3AKR1C2PTGS1TAS2R14 | |
| SCHEMBL16914511 | 0.78 | CA1 (0.55) | PTGS2ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL26979278 | 0.78 | AKR1C2 (0.44) | PTGS2AKR1C3AKR1C2PTGS1TAS2R14 | |
| SCHEMBL22628276 | 0.78 | AKR1C2 (0.44) | PTGS2AKR1C3AKR1C2PTGS1TAS2R14 | |
| SCHEMBL23141189 | 0.77 | PTGS2 (0.43) | PTGS2AKR1C3AKR1C2PTGS1TAS2R14 | |
| SCHEMBL1194182 | 0.77 | ALDH1A1 (0.53) | PTGS2AKR1C3AKR1C2PTGS1TAS2R14 | |
| SCHEMBL21814272 | 0.77 | KEAP1 (0.58) | PTGS2AKR1C3AKR1C2PTGS1TAS2R14 | |
| SCHEMBL29377565 | 0.77 | ALDH1A1 (0.53) | PTGS2AKR1C3AKR1C2PTGS1TAS2R14 | |
| SCHEMBL2342293 | 0.77 | TSHR (0.57) | PTGS2AKR1C3AKR1C2PTGS1TAS2R14 | |
| SCHEMBL15123097 | 0.77 | ALDH1A1 (0.49) | PTGS2AKR1C3AKR1C2PTGS1TAS2R14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8404893-B2 | Pentafluorosulfanylbenzoylguanidines, processes for their preparation, their use as medicaments or diagnostic aids, and medicaments comprising them | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2013-03-26 | — | — | US | disclosed |
| US-20110306670-A1 | PENTAFLUOROSULFANYLBENZOYLGUANIDINES, PROCESSES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS OR DIAGNOSTIC AIDS, AND MEDICAMENTS COMPRISING THEM | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2011-12-15 | — | — | US | disclosed |
| US-8008352-B2 | N-[2-Chloro-4-pentafluorosulfanylbenzoyl]guanidine; ischemia, reperfusion, arrythmia angina pectoris; inhibit the cellular sodium-proton antiporter (Na+/H+ exchanger, NHE); stability, longer half-life in vivo, high bioavailability | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2011-08-30 | — | — | US | disclosed |
| US-7932416-B2 | Prepared by electrophilic aromatic substitution via halogenation, chlorosulfonation or nitration of a pentafluorosulfanylbenzene; 2-Methyl-5-nitro-4-pentafluorosulfuranylbenzoic acid; for liquid crystals, polymers, pesticides, herbicides, fungicides, nematocides, parasiticides, insecticides, acaricides | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2011-04-26 | — | — | US | disclosed |
| US-7932416-B2 | Prepared by electrophilic aromatic substitution via halogenation, chlorosulfonation or nitration of a pentafluorosulfanylbenzene; 2-Methyl-5-nitro-4-pentafluorosulfuranylbenzoic acid; for liquid crystals, polymers, pesticides, herbicides, fungicides, nematocides, parasiticides, insecticides, acaricides | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2011-04-26 | — | — | US | disclosed |
| US-7659429-B2 | Process for preparing 4-pentafluorosulfanylbenzoylguanidines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-02-09 | — | — | US | disclosed |
| US-7659429-B2 | Process for preparing 4-pentafluorosulfanylbenzoylguanidines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2010-02-09 | — | — | US | disclosed |
| US-7622611-B2 | Pentafluorosulfanylbenzoylguanidines, process for their preparation, use as a medicament or diagnostic aid, and medicament comprising same | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-11-24 | — | — | US | disclosed |
| US-7622611-B2 | Pentafluorosulfanylbenzoylguanidines, process for their preparation, use as a medicament or diagnostic aid, and medicament comprising same | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-11-24 | — | — | US | disclosed |
| US-20090036704-A1 | Process for Preparing 4-Pentafluorosulfanylbenzoylguanidines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2009-02-05 | — | — | US | disclosed |
| US-7317124-B2 | Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as valuable synthetic intermediates | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2008-01-08 | — | — | US | disclosed |
| EP-1685096-B1 | PENTAFLUOROSULFANYL BENZOYLGUANIDINES, METHOD FOR THEIR PRODUCTION, THEIR USE AS MEDICAMENTS OR DIAGNOSTIC AGENTS AND MEDICAMENT CONTAINING THE SAME | SANOFI AVENTIS DEUTSCHLAND (DE) | 2007-07-25 | — | — | EP | disclosed |
| US-20070106094-A1 | Process For Preparing 4-Pentafluorosulfanylbenzoylguanidines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-05-10 | — | — | US | disclosed |
| US-20070106094-A1 | Process For Preparing 4-Pentafluorosulfanylbenzoylguanidines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-05-10 | — | — | US | disclosed |
| US-20070106094-A1 | Process For Preparing 4-Pentafluorosulfanylbenzoylguanidines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2007-05-10 | — | — | US | disclosed |
| US-7126026-B2 | Process for preparing 4-pentafluorosulfanylbenzoylguanidines | SANOFI-AVENTIS DEUTSCHLAND GMBH (DE) | 2006-10-24 | — | — | US | disclosed |
| US-20050148652-A1 | Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as valuable synthetic intermediates | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-07-07 | — | — | US | disclosed |
| US-20050131070-A1 | Process for preparing 4-pentafluorosulfanylbenzoylguanidines | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-06-16 | — | — | US | disclosed |
| US-20050124666-A1 | Pentafluorosulfanylbenzoylguanidines, process for their preparation, use as a medicament or diagnostic aid, and medicament comprising same | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2005-06-09 | — | — | US | disclosed |
| US-20030216476-A1 | Pentafluorosulfanylbenzoylguanidines, processes for their preparation, their use as medicaments or diagnostic aids, and medicaments comprising them | AVENTIS PHARMA DEUTSHCHLAND GMBH (DE) | 2003-11-20 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306670-A1 | PENTAFLUOROSULFANYLBENZOYLGUANIDINES, PROCESSES FOR THEIR PREPARATION, THEIR USE AS MEDICAMENTS OR DIAGNOSTIC AIDS, AND MEDICAMENTS COMPRISING THEM | TNNI3, TNNT2, SDHB | RXRB 2805/4885RXRA 3216/4885PTGS2 789/4885 |
| US-20050148652-A1 | Ortho-substituted pentafluorosulfanylbenzenes, process for their preparation and their use as valuable synthetic intermediates | PFAS, DDT, PNPO | RXRB 222/4885RXRA 725/4885PTGS2 3963/4885 |
| US-20090036704-A1 | Process for Preparing 4-Pentafluorosulfanylbenzoylguanidines | NHERF1, SLC9A1, SLC5A1 | RXRB 4090/4885RXRA 4214/4885PTGS2 2027/4885 |
| US-20050131070-A1 | Process for preparing 4-pentafluorosulfanylbenzoylguanidines | NHERF1, SLC9A1, SLC5A1 | RXRB 4090/4885RXRA 4214/4885PTGS2 2027/4885 |
| US-20030216476-A1 | Pentafluorosulfanylbenzoylguanidines, processes for their preparation, their use as medicaments or diagnostic aids, and medicaments comprising them | TNNI3, TNNT2, SDHB | RXRB 2936/4885RXRA 3282/4885PTGS2 696/4885 |
| US-20070106094-A1 | Process For Preparing 4-Pentafluorosulfanylbenzoylguanidines | PAH, NCEH1, PNMT | RXRB 3793/4885RXRA 4033/4885PTGS2 2493/4885 |
| US-20050124666-A1 | Pentafluorosulfanylbenzoylguanidines, process for their preparation, use as a medicament or diagnostic aid, and medicament comprising same | TNNI3, TNNT2, FABP3 | RXRB 2390/4885RXRA 2496/4885PTGS2 720/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.