Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 2/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | PIK3C3 | Q8NEB9 | 7/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CRHBP | P24387 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16923729 | 0.81 | PIK3C3 (0.37) | PIK3C3 | |
| SCHEMBL16916948 | 0.80 | PIK3C3 (0.48) | HTR6PIK3C3 | |
| SCHEMBL18232220 | 0.79 | PIK3C3 (0.52) | HTR6ALDH1A1PIK3C3HTT | |
| SCHEMBL16916846 | 0.78 | PIK3C3 (0.52) | HTR6PIK3C3 | |
| SCHEMBL16923715 | 0.77 | PIK3C3 (0.49) | HTR6TSHRPIK3C3SMN1; SMN2GAA | |
| SCHEMBL19662371 | 0.75 | L3MBTL1 (0.45) | BRD4HTR6POLBPIK3C3MAPT | |
| SCHEMBL16916911 | 0.75 | PIK3C3 (0.48) | BRD4HTR6ALDH1A1TSHRPIK3C3 | |
| SCHEMBL16923789 | 0.74 | HTR6 (0.38) | HTR6PIK3C3 | |
| SCHEMBL16923791 | 0.73 | PIK3C3 (0.54) | BRD4HTR6TSHRPIK3C3MAPT | |
| SCHEMBL16923704 | 0.71 | PIK3C3 (0.77) | PIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10202373-B2 | Heteroaryls and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2019-02-12 | — | — | US | disclosed |
| US-20160333007-A1 | HETEROARYLS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-11-17 | — | — | US | disclosed |
| US-20160333007-A1 | HETEROARYLS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-11-17 | — | — | US | disclosed |
| WO-2015108881-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-07-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160333007-A1 | HETEROARYLS AND USES THEREOF | VPS35, VPS4B, VPS26B | BRD4 58/4885HTR6 2282/4885POLB 1712/4885 |
| US-10202373-B2 | Heteroaryls and uses thereof | VPS35, VPS4B, VPS26B | BRD4 58/4885HTR6 2282/4885POLB 1712/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.