Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3C3 | Q8NEB9 | 14/20 | 0.48 |
| ▸ | HTR6 | P50406 | 2/20 | 0.36 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | BCR | P11274 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16923729 | 0.85 | PIK3C3 (0.37) | PIK3C3 | |
| SCHEMBL16923715 | 0.84 | PIK3C3 (0.49) | PIK3C3HTR6 | |
| SCHEMBL19278216 | 0.83 | ABL1 (0.36) | PIK3C3HTR6ABL1BCR | |
| SCHEMBL16916846 | 0.82 | PIK3C3 (0.52) | PIK3C3HTR6ABL1BCR | |
| SCHEMBL16916911 | 0.81 | PIK3C3 (0.48) | PIK3C3HTR6 | |
| SCHEMBL19662371 | 0.81 | L3MBTL1 (0.45) | PIK3C3HTR6ABL1BCR | |
| SCHEMBL16923795 | 0.81 | PIK3C3 (0.37) | PIK3C3HTR6 | |
| SCHEMBL16923725 | 0.81 | PIK3C3 (0.34) | PIK3C3HTR6 | |
| SCHEMBL16923789 | 0.80 | HTR6 (0.38) | PIK3C3HTR6 | |
| SCHEMBL16923728 | 0.80 | BRD4 (0.42) | PIK3C3HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10202373-B2 | Heteroaryls and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2019-02-12 | — | — | US | disclosed |
| US-10202373-B2 | Heteroaryls and uses thereof | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2019-02-12 | — | — | US | disclosed |
| EP-3094326-A1 | HETEROARYLS AND USES THEREOF | Millennium Pharmaceuticals, Inc. (US) | 2016-11-23 | — | — | EP | disclosed |
| US-20160333007-A1 | HETEROARYLS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-11-17 | — | — | US | disclosed |
| US-20160333007-A1 | HETEROARYLS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-11-17 | — | — | US | disclosed |
| US-20160333007-A1 | HETEROARYLS AND USES THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2016-11-17 | — | — | US | disclosed |
| WO-2015108881-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-07-23 | — | — | WO | disclosed |
| WO-2015108881-A1 | HETEROARYLS AND USES THEREOF | MILLENNIUM PHARMACEUTICALS, INC. (US) | 2015-07-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160333007-A1 | HETEROARYLS AND USES THEREOF | VPS35, VPS4B, VPS26B | PIK3C3 981/4885HTR6 2282/4885ABL1 1687/4885 |
| US-10202373-B2 | Heteroaryls and uses thereof | VPS35, VPS4B, VPS26B | PIK3C3 981/4885HTR6 2282/4885ABL1 1687/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.