Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.65 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.65 |
| ▸ | RNF114 | Q9Y508 | 1/20 | 0.61 |
| ▸ | YAP1 | P46937 | 1/20 | 0.56 |
| ▸ | TEAD4 | Q15561 | 1/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | ACHE | P22303 | 1/20 | 0.53 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.52 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.52 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.52 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16938347 | 0.85 | MEN1 (0.68) | L3MBTL1RNF114YAP1TEAD4ACHE | |
| SCHEMBL14665712 | 0.81 | RNF114 (0.60) | L3MBTL1RNF114YAP1TEAD4ACHE | |
| SCHEMBL14541216 | 0.80 | CACNA1H (0.67) | ALDH1A1EGFRACHE | |
| SCHEMBL10050566 | 0.80 | EGFR (0.64) | L3MBTL1RNF114YAP1TEAD4EGFR | |
| SCHEMBL31574504 | 0.79 | MEN1 (0.59) | L3MBTL1RNF114YAP1TEAD4ACHE | |
| SCHEMBL10074852 | 0.78 | POLB (0.68) | ALDH1A1L3MBTL1RNF114 | |
| SCHEMBL12857571 | 0.78 | YAP1 (0.74) | L3MBTL1YAP1TEAD4 | |
| SCHEMBL25372299 | 0.76 | ALDH1A1 (0.63) | ALDH1A1PKMEGFR | |
| SCHEMBL25372296 | 0.76 | ALDH1A1 (0.63) | ALDH1A1PKMEGFR | |
| SCHEMBL14540876 | 0.74 | MAPT (0.73) | ALDH1A1PKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2716285-B9 | Compounds for treating and/or preventing diseases associated with bone loss | CENTRE NAT DE LA RECH SCIENT -CNRS- (FR) | 2017-03-01 | — | — | EP | claimed |
| EP-2716285-B1 | Compounds for treating and/or preventing diseases associated with bone loss | CENTRE NAT RECH SCIENT (FR) | 2016-04-27 | — | — | EP | claimed |
| JP-2012500393-A | — | — | 2012-01-05 | — | — | JP | claimed |
| US-20110212974-A1 | METHOD FOR IDENTIFYING COMPOUNDS USEFUL FOR TREATING AND/OR PREVENTING DISEASE-ASSOCIATED BONE LOSS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) | 2011-09-01 | — | — | US | claimed |
| EP-2331967-A2 | NEW METHOD FOR IDENTIFYING COMPOUNDS USEFUL FOR TREATING AND/OR PREVENTING DISEASES ASSOCIATED WITH BONE LOSS | Centre National de la Recherche Scientifique (C.N.R.S) (FR) | 2011-06-15 | — | — | EP | claimed |
| WO-2010020647-A2 | NEW METHOD FOR IDENTIFYING COMPOUNDS USEFUL FOR TREATING AND/OR PREVENTING DISEASE-ASSOCIATED BONE LOSS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2010-02-25 | — | — | WO | claimed |
| EP-2716285-B9 | Compounds for treating and/or preventing diseases associated with bone loss | CENTRE NAT DE LA RECH SCIENT -CNRS- (FR) | 2017-03-01 | — | — | EP | disclosed |
| EP-2716285-B1 | Compounds for treating and/or preventing diseases associated with bone loss | CENTRE NAT RECH SCIENT (FR) | 2016-04-27 | — | — | EP | disclosed |
| EP-2331967-B1 | NEW METHOD FOR IDENTIFYING COMPOUNDS USEFUL FOR TREATING AND/OR PREVENTING DISEASES ASSOCIATED WITH BONE LOSS | CENTRE NAT RECH SCIENT (FR) | 2015-11-04 | — | — | EP | disclosed |
| US-9091678-B2 | Method for identifying compounds useful for treating and/or preventing disease-associated bone loss | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2015-07-28 | — | — | US | disclosed |
| US-9091678-B2 | Method for identifying compounds useful for treating and/or preventing disease-associated bone loss | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2015-07-28 | — | — | US | disclosed |
| US-20110212974-A1 | METHOD FOR IDENTIFYING COMPOUNDS USEFUL FOR TREATING AND/OR PREVENTING DISEASE-ASSOCIATED BONE LOSS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) | 2011-09-01 | — | — | US | disclosed |
| US-20110212974-A1 | METHOD FOR IDENTIFYING COMPOUNDS USEFUL FOR TREATING AND/OR PREVENTING DISEASE-ASSOCIATED BONE LOSS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) | 2011-09-01 | — | — | US | disclosed |
| EP-2331967-A2 | NEW METHOD FOR IDENTIFYING COMPOUNDS USEFUL FOR TREATING AND/OR PREVENTING DISEASES ASSOCIATED WITH BONE LOSS | Centre National de la Recherche Scientifique (C.N.R.S) (FR) | 2011-06-15 | — | — | EP | disclosed |
| WO-2010020647-A2 | NEW METHOD FOR IDENTIFYING COMPOUNDS USEFUL FOR TREATING AND/OR PREVENTING DISEASE-ASSOCIATED BONE LOSS | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS) (FR) | 2010-02-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110212974-A1 | METHOD FOR IDENTIFYING COMPOUNDS USEFUL FOR TREATING AND/OR PREVENTING DISEASE-ASSOCIATED BONE LOSS | DOCK5, ARHGDIB, ARHGDIA | ALDH1A1 3992/4885L3MBTL1 1821/4885RNF114 3542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.