Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.79 |
| ▸ | RAB9A | P51151 | 5/20 | 0.79 |
| ▸ | LMNA | P02545 | 4/20 | 0.79 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.79 |
| ▸ | RECQL | P46063 | 1/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.72 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.72 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.72 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.72 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.72 |
| ▸ | HTT | P42858 | 3/20 | 0.72 |
| ▸ | GSK3A | P49840 | 2/20 | 0.71 |
| ▸ | GSK3B | P49841 | 2/20 | 0.71 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.71 |
| ▸ | HPGD | P15428 | 2/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 2/20 | 0.61 |
| ▸ | EGFR | P00533 | 1/20 | 0.60 |
| ▸ | TSHR | P16473 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16944482 | 0.86 | RECQL (1.00) | NPC1RAB9ALMNASMN1; SMN2RECQL | |
| SCHEMBL16157061 | 0.86 | GSK3A (0.75) | NPC1RAB9ALMNASMN1; SMN2HTT | |
| SCHEMBL16944471 | 0.85 | GSK3B (0.95) | NPC1RAB9ALMNASMN1; SMN2HTT | |
| SCHEMBL3612855 | 0.85 | RAB9A (0.97) | NPC1RAB9ALMNASMN1; SMN2RECQL | |
| SCHEMBL16157164 | 0.84 | RAB9A (0.77) | NPC1RAB9ALMNASMN1; SMN2RECQL | |
| SCHEMBL16944487 | 0.84 | LMNA (1.00) | NPC1RAB9ALMNASMN1; SMN2RECQL | |
| SCHEMBL14604115 | 0.84 | GSK3B (0.91) | NPC1RAB9ALMNASMN1; SMN2HTT | |
| SCHEMBL14604069 | 0.83 | GSK3B (1.00) | NPC1RAB9ALMNASMN1; SMN2HTT | |
| SCHEMBL16157036 | 0.81 | EGFR (0.79) | NPC1RAB9ALMNASMN1; SMN2HTT | |
| SCHEMBL16944446 | 0.80 | GSK3B (0.66) | NPC1RAB9ALMNASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9669014-B2 | Small molecule inhibitors of superoxide dismutase expression | NORTHWESTERN UNIVERSITY (US) | 2017-06-06 | — | — | US | disclosed |
| US-9669014-B2 | Small molecule inhibitors of superoxide dismutase expression | NORTHWESTERN UNIVERSITY (US) | 2017-06-06 | — | — | US | disclosed |
| US-20160214969-A1 | SMALL MOLECULE INHIBITORS OF SUPEROXIDE DISMUTASE EXPRESSION | NORTHWESTERN UNIVERSITY (US) | 2016-07-28 | — | — | US | disclosed |
| US-20160214969-A1 | SMALL MOLECULE INHIBITORS OF SUPEROXIDE DISMUTASE EXPRESSION | NORTHWESTERN UNIVERSITY (US) | 2016-07-28 | — | — | US | disclosed |
| US-20150210679-A1 | SMALL MOLECULE INHIBITORS OF SUPEROXIDE DISMUTASE EXPRESSION | NORTHWESTERN UNIVERSITY (US) | 2015-07-30 | — | — | US | disclosed |
| US-20150210679-A1 | SMALL MOLECULE INHIBITORS OF SUPEROXIDE DISMUTASE EXPRESSION | NORTHWESTERN UNIVERSITY (US) | 2015-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160214969-A1 | SMALL MOLECULE INHIBITORS OF SUPEROXIDE DISMUTASE EXPRESSION | SOD1, SOD3, CAT | NPC1 3089/4885RAB9A 1431/4885LMNA 3745/4885 |
| US-20150210679-A1 | SMALL MOLECULE INHIBITORS OF SUPEROXIDE DISMUTASE EXPRESSION | SOD1, SOD3, CAT | NPC1 3089/4885RAB9A 1431/4885LMNA 3745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.