Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 1.00 |
| ▸ | RECQL | P46063 | 1/20 | 0.77 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.77 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.77 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.77 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.77 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.77 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.77 |
| ▸ | RAB9A | P51151 | 4/20 | 0.77 |
| ▸ | HTT | P42858 | 4/20 | 0.77 |
| ▸ | NPC1 | O15118 | 3/20 | 0.77 |
| ▸ | STAT1 | P42224 | 1/20 | 0.61 |
| ▸ | TP53 | P04637 | 1/20 | 0.61 |
| ▸ | GSK3A | P49840 | 2/20 | 0.60 |
| ▸ | GSK3B | P49841 | 2/20 | 0.60 |
| ▸ | PKM | P14618 | 1/20 | 0.60 |
| ▸ | HPGD | P15428 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3612855 | 0.88 | RAB9A (0.97) | LMNARECQLCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL16944482 | 0.87 | RECQL (1.00) | LMNARECQLCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL16157164 | 0.87 | RAB9A (0.77) | LMNARECQLCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL16211143 | 0.85 | EGFR (0.80) | LMNACYP1A2CYP2C9CYP2C19SMN1; SMN2 | |
| SCHEMBL16944461 | 0.84 | NPC1 (0.79) | LMNARECQLCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL14603735 | 0.84 | PTGS2 (0.76) | LMNACYP1A2CYP2C19SMN1; SMN2RAB9A | |
| SCHEMBL21041291 | 0.80 | GSK3B (0.71) | LMNARECQLCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL16157156 | 0.80 | RAB9A (0.82) | LMNARECQLCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL24393914 | 0.79 | GSK3B (0.76) | LMNARECQLCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL9058883 | 0.78 | HTT (0.79) | LMNARECQLCYP1A2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9669014-B2 | Small molecule inhibitors of superoxide dismutase expression | NORTHWESTERN UNIVERSITY (US) | 2017-06-06 | — | — | US | disclosed |
| US-9669014-B2 | Small molecule inhibitors of superoxide dismutase expression | NORTHWESTERN UNIVERSITY (US) | 2017-06-06 | — | — | US | disclosed |
| US-20160214969-A1 | SMALL MOLECULE INHIBITORS OF SUPEROXIDE DISMUTASE EXPRESSION | NORTHWESTERN UNIVERSITY (US) | 2016-07-28 | — | — | US | disclosed |
| US-20160214969-A1 | SMALL MOLECULE INHIBITORS OF SUPEROXIDE DISMUTASE EXPRESSION | NORTHWESTERN UNIVERSITY (US) | 2016-07-28 | — | — | US | disclosed |
| US-20150210679-A1 | SMALL MOLECULE INHIBITORS OF SUPEROXIDE DISMUTASE EXPRESSION | NORTHWESTERN UNIVERSITY (US) | 2015-07-30 | — | — | US | disclosed |
| US-20150210679-A1 | SMALL MOLECULE INHIBITORS OF SUPEROXIDE DISMUTASE EXPRESSION | NORTHWESTERN UNIVERSITY (US) | 2015-07-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160214969-A1 | SMALL MOLECULE INHIBITORS OF SUPEROXIDE DISMUTASE EXPRESSION | SOD1, SOD3, CAT | LMNA 3745/4885RECQL 1048/4885CYP1A2 3727/4885 |
| US-20150210679-A1 | SMALL MOLECULE INHIBITORS OF SUPEROXIDE DISMUTASE EXPRESSION | SOD1, SOD3, CAT | LMNA 3745/4885RECQL 1048/4885CYP1A2 3727/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.