Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DDR1 | Q08345 | 3/20 | 0.34 |
| ▸ | RAPGEF4 | Q8WZA2 | 7/20 | 0.34 |
| ▸ | HTR6 | P50406 | 2/20 | 0.33 |
| ▸ | BPTF | Q12830 | 1/20 | 0.31 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.31 |
| ▸ | PNMT | P11086 | 1/20 | 0.31 |
| ▸ | MMP2 | P08253 | 1/20 | 0.30 |
| ▸ | MMP3 | P08254 | 1/20 | 0.30 |
| ▸ | MMP9 | P14780 | 1/20 | 0.30 |
| ▸ | MMP13 | P45452 | 1/20 | 0.30 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.30 |
| ▸ | MGLL | Q99685 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15358112 | 0.77 | RAPGEF4 (0.44) | DDR1RAPGEF4PSIP1 | |
| Hydrochloric Acid SCHEMBL16528414 | 0.75 | RAPGEF4 (0.42) | DDR1RAPGEF4PSIP1 | |
| SCHEMBL12641734 | 0.72 | ALDH1A1 (0.38) | BPTFKAT2BKMT2APNMT | |
| Hydrochloric Acid SCHEMBL29904871 | 0.71 | BPTF (0.37) | BPTFKAT2BKMT2APNMT | |
| SCHEMBL15803862 | 0.69 | LOX (0.34) | BPTFKAT2BKMT2AMMP2MMP9 | |
| SCHEMBL23134641 | 0.68 | PNMT (0.35) | BPTFKAT2BPNMT | |
| SCHEMBL1106459 | 0.68 | PTGS2 (0.42) | BPTFKAT2BKMT2APNMT | |
| SCHEMBL16541861 | 0.63 | RAPGEF4 (0.41) | DDR1RAPGEF4HTR6PSIP1 | |
| SCHEMBL23121361 | 0.62 | NPC1 (0.45) | KMT2A | |
| SCHEMBL15799041 | 0.62 | BRD4 (0.50) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2566479-A1 | AZAINDAZOLES | GlaxoSmithKline LLC (US) | 2013-03-13 | — | — | EP | disclosed |
| WO-2012005805-A1 | AZAINDAZOLES | GLAXOSMITHKLINE LLC (US) | 2012-01-12 | — | — | WO | disclosed |