Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 5/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PLA2G7 | Q13093 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4187732 | 0.86 | KMT2A (0.54) | ALDH1A1MAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL4202584 | 0.86 | RAB9A (0.51) | ALOX15ALDH1A1MAPTLMNAKDM4E | |
| SCHEMBL4186735 | 0.84 | ALOX15 (0.65) | ALOX15LMNACYP1A2CYP2C19TP53 | |
| SCHEMBL4199011 | 0.84 | NPC1 (0.53) | ALOX15ALDH1A1MAPTLMNAKDM4E | |
| SCHEMBL30917977 | 0.81 | CHRM3 (0.46) | ALOX15MAPTTHRB | |
| SCHEMBL4201444 | 0.81 | ALOX15 (0.51) | ALOX15MAPTLMNAKDM4EHTT | |
| SCHEMBL29198676 | 0.81 | CHRM3 (0.46) | ALOX15MAPTTHRB | |
| SCHEMBL168618 | 0.76 | MEN1 (0.63) | ALDH1A1MAPTLMNAKDM4EMAPK1 | |
| SCHEMBL23992170 | 0.76 | KDM4E (0.49) | ALDH1A1LMNAKDM4EMAPK1SMN1; SMN2 | |
| SCHEMBL4205361 | 0.76 | RAB9A (0.56) | ALOX15ALDH1A1MAPTLMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2609091-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | Lead Discovery Center GmbH (DE) | 2013-07-03 | — | — | EP | disclosed |
| WO-2012028332-A1 | PHARMACEUTICALLY ACTIVE COMPOUNDS AS AXL INHIBITORS | LEAD DISCOVERY CENTER GMBH (DE) | 2012-03-08 | — | — | WO | disclosed |